Lymphocyte antigen 96 (Ly96)

Binds bacterial lipopolysaccharide (LPS) (PubMed:22532668). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components in Gram-positive and Gram- negative bacteria.

Enhances TLR4-dependent activation of NF-kappa- B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10725698).