LYPLAL1 Antibodies

AND LYPLAL1 ELISA kits, LYPLAL1 Proteins

Many biological assays use antibodies to detect LYPLAL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LYPLAL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LYPLAL1 antibodies...

We validate the specificity of these antibodies to LYPLAL1 by testing them on tissues known to express LYPLAL1 positively and negatively. Browse below to find the LYPLAL1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LYPLAL1 Infographic by Boster Bio

All LYPLAL1 Products

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LYPLAL1 (NM_138794) Human Recombinant Protein

Coomassie blue staining of purified LYPLAL1 protein

$1249
Cat # PROTQ5VWZ2
20 µg

LYPLAL1 (NM_138794) Human Over-expression Lysate

Human

$628
Cat # LS127018
20 µg, 100 µg

LYPLAL1 Overview

Facts about Lysophospholipase-like protein 1.

LYPLAL1 3D structure. Source: alphafold

Lysophospholipase-like protein 1 (LYPLAL1)

Has depalmitoylating activity toward KCNMA1. Doesn't exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active website.

Gene Information

Human
Gene Name:	LYPLAL1
Uniprot:	Q5VWZ2
Entrez:	127018

Family

Belongs to:

AB hydrolase superfamily

Alternative Names

EC 3.1.2.-; FLJ99730; KIAA1238; lysophospholipase-like 1; lysophospholipase-like protein 1; Q96AV0

Molecular Weight

Mass (kDA):
26.316 kDA

Genomic Context


Human

Location:	1q41
Sequence:	1; NC_000001.11 (219173831..219445121)

Subcellular Localizations

[Isoform 1]: Cytoplasm, cytosol.; [Isoform 2]: Cytoplasm, cytosol.

Diseases

Obesity
Obesity, Abdominal
Diabetes Mellitus
Insulin Resistance
Diabetes Mellitus, Non-insulin-dependent
Liver Diseases
Dyslipidemias
Nonalcoholic Fatty Liver Disease
Cardiovascular Diseases
Metabolic Syndrome X
Malignant Neoplasms
Scleral Diseases

Colorectal Cancer
Impaired Glucose Tolerance
Fatty Liver
Severe Myopia
Congenital Abnormality
Steatohepatitis
Hyperinsulinism

Pathways

Glucose Homeostasis
Histone Deacetylation
Protein Palmitoylation
Lipid Modification
Pathogenesis

PTMs

Depalmitoylation

Deacetylation

Palmitoylation

Research Areas

Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LYPLAL1

References

PMID: 22399288 by Tian L., et al. Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels.

PMID: 22052940 by Burger M., et al. Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases.