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- Table of Contents
Legumain Antibodies
AND LGMN ELISA kits, Legumain Proteins
Many biological assays use antibodies to detect Legumain, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Legumain in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Legumain antibodies...
Designing a Western blot for Legumain? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the LGMN Western Blot GuideLGMN Infographic by Boster Bio
All LGMN Products
Product
Figures
Specificity
Applications
Price
Human Legumain(total) ELISA Kit PicoKine®
1 Citations
Human
ELISA
$499
Cat # EK1566
96 wells/kit, with removable strips.
Cat # EK1566
96 wells/kit, with removable strips.
Mouse Legumain(total) ELISA Kit PicoKine®
1 Citations
Mouse
ELISA
$499
Cat # EK1567
96 wells/kit, with removable strips.
Cat # EK1567
96 wells/kit, with removable strips.
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A06476-1
100 μg/vial
Cat # A06476-1
100 μg/vial
SDS-PAGE
$250
Cat # PROTO89017
Starting from 10ug
Cat # PROTO89017
Starting from 10ug
LGMN Overview
Facts about Legumain.
Legumain (LGMN)
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions.
Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR.
Gene Information
| Human | |
|---|---|
| Gene Name: | LGMN |
| Uniprot: | Q99538 |
| Entrez: | 5641 |
Family
| Belongs to: |
|---|
| peptidase C13 family |
Alternative Names
AEP; Asparaginyl Endopeptidase; cysteine protease 1; Legumain; LGMN; LGMN1; Protease, cysteine 1; protease, cysteine, 1 (legumain); PRSC1EC 3.4.22.34
Molecular Weight
Mass (kDA):
49.411 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q32.12 |
| Sequence: | 14; NC_000014.9 (92703809..92748627, complement) |
Tissue Specificity
Ubiquitous. Particularly abundant in kidney, heart and placenta.
Subcellular Localizations
Lysosome.
Diseases
- Hyperdiploidy
- Liver Carcinoma
- Allelic Imbalance
- Endometrial Polyp
- Tissue Adhesions
- Acute Lymphocytic Leukemia
- Hepatocarcinogenesis
- Diabetes Mellitus
- Carcinoma
- Carcinogenesis
Pathways
- Cell Growth
- Cell Adhesion
- Regeneration
- Cell Proliferation
PTMs
- Disulfide bond
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LGMN
bosterbio.com/bosterbio-gene-info-cards/LGMN
References
PMID: 9065484 by Chen J.-M., et al. Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase.
PMID: 8893817 by Tanaka T., et al. Molecular cloning of a human cDNA encoding putative cysteine protease (PRSC1) and its chromosome assignment to 14q32.1.
1 Publications of Boster Legumain Antibodies & ELISA Kits
- PubMed ID: 32229193, Chen HC,Rui W,You SY,Liu XW,Huang J,Chen HY.Evaluation of the anti-cervical canc...
*More publications can be found for each product on its corresponding product page