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- Table of Contents
MAD1L1 Antibodies
AND MAD1L1 ELISA kits, MAD1L1 Proteins
Many biological assays use antibodies to detect MAD1L1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAD1L1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAD1L1 antibodies...
Designing an IHC experiment for MAD1L1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the MAD1L1 IHC GuideMAD1L1 Infographic by Boster Bio
All MAD1L1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9262
100 μg/vial
Cat # PB9262
100 μg/vial
MAD1L1 Overview
Facts about Mitotic spindle assembly checkpoint protein MAD1.
Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1)
Part of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores.
Has a role in the proper positioning of the septum. Required for anchoring MAD2L1 into the nuclear periphery.
Gene Information
| Human | |
|---|---|
| Gene Name: | MAD1L1 |
| Uniprot: | Q9Y6D9 |
| Entrez: | 8379 |
Family
| Belongs to: |
|---|
| MAD1 family |
Alternative Names
hMAD1; HsMAD1; MAD1 mitotic arrest deficient-like 1 (yeast); MAD1; MAD1L1; MAD1-like protein 1; MAD1yeast, homolog-like 1; Mitotic checkpoint MAD1 protein homolog; PIG9; Tax-binding protein 181; TP53I9; tumor protein p53 inducible protein 9; TXBP181; TXBP181MAD1 (mitotic arrest deficient, yeast, homolog)-like 1
Molecular Weight
Mass (kDA):
83.067 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7p22.3 |
| Sequence: | 7; NC_000007.14 (1815795..2232945, complement) |
Tissue Specificity
Expressed weakly at G0/G1 and highly at late S and G2/M phase.
Subcellular Localizations
Nucleus. Chromosome, centromere, kinetochore. Nucleus envelope. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Detected at the nucleus envelope during interphase (PubMed:22351768). From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody. Detected at kinetochores during prometaphase (PubMed:22351768). Colocalizes with NEK2 at the kinetochore (PubMed:14978040). Colocalizes with IK at spindle p
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Aneuploidy
- Cell Transformation, Neoplastic
- Leukemia
- Carcinogenesis
- Sudden Infant Death Syndrome
- Malignant Neoplasm Of Breast
- Genomic Instability
- Lung Neoplasms
- Malignant Neoplasm Of Lung
- Malignant Neoplasm Of Stomach
Interacting Proteins
- ALOX5
- BAG5
- CCDC94
- CWF19L2
- HAUS1
- LGALSL
- MAD2L1
- MFAP1
- NEBL
- PSMA1
Pathways
- Cell Cycle
- Spindle Checkpoint
- Mitosis
- Anaphase
- Spindle Assembly
- Localization
- Spindle Assembly Checkpoint
- Metaphase
- Cell Proliferation
- Chromosome Segregation
- Kinetochore Localization
- Cell Growth
- Cell Cycle Arrest
PTMs
- Phosphorylation
- Acetylation
- Methylation
- Deacetylation
Research Areas
- Cancer
- Cell Cycle and Replication
- DNA Repair
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAD1L1
bosterbio.com/bosterbio-gene-info-cards/MAD1L1
References
PMID: 9546394 by Jin D.-Y., et al. Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1.
PMID: 10198256 by Seeley T.W., et al. Phosphorylation of human MAD1 by the BUB1 kinase in vitro.