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Protein maelstrom homolog Antibodies
AND MAEL ELISA kits, Protein maelstrom homolog Proteins
Many biological assays use antibodies to detect Protein maelstrom homolog, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein maelstrom homolog in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein maelstrom homolog antibodies...
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MAEL Overview
Facts about Protein maelstrom homolog.
Protein maelstrom homolog (MAEL)
Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts through the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons.
Its association with piP- bodies indicates a participation in the secondary piRNAs metabolic procedure. Required for the localization of germ-cell facets to the meiotic nuage (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | MAEL |
| Uniprot: | Q96JY0 |
| Entrez: | 84944 |
Family
| Belongs to: |
|---|
| maelstrom family |
Alternative Names
cancer/testis antigen 128; CT128; FLJ14904; maelstrom homolog (Drosophila); protein maelstrom homolog; RP11-102C16.1
Molecular Weight
Mass (kDA):
49.219 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q24.1 |
| Sequence: | 1; NC_000001.11 (166921121..167022214) |
Tissue Specificity
Testis-specific. Expressed in various cancer cell lines, probably due to demethylation of its promoter.
Subcellular Localizations
Cytoplasm. Nucleus. Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs (By similarity).
Diseases
- Malignant Neoplasms
- Colorectal Neoplasms
- Colorectal Cancer
- Testicular Neoplasms
- Male Infertility
- Precocious Puberty
- Gonorrhea
- Genomic Instability
- Angina Pectoris
- Sterility
- Infertility
- Myocardial Infarction
- Urethral Diseases
Pathways
- Localization
- Methylation
- Dna Methylation
- Spermatogenesis
- Meiosis
- Transport
- Rna Processing
- Oogenesis
- Gene Silencing
- Immune Response
- Larval Development
- Nuclear Transport
- Oocyte Development
PTMs
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAEL
bosterbio.com/bosterbio-gene-info-cards/MAEL
References
PMID: 19693694 by Xiao L., et al. Identification of a novel human cancer/testis gene MAEL that is regulated by DNA methylation.