Mastermind-like protein 1 Antibodies

AND MAML1 ELISA kits, Mastermind-like protein 1 Proteins

Many biological assays use antibodies to detect Mastermind-like protein 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Mastermind-like protein 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Mastermind-like protein 1 antibodies...

We validate the specificity of these antibodies to Mastermind-like protein 1 by testing them on tissues known to express MAML1 positively and negatively. Browse below to find the MAML1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MAML1 Infographic by Boster Bio

All MAML1 Products

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MAML1 (NM_014757) Human Over-expression Lysate

Human

$960
Cat # LS009794
20 µg, 100 µg

Anti-MAML1 Antibody Picoband®

Western blot analysis of MAML1 using anti-MAML1 antibody (A03990-2)

IF analysis of MAML1 using anti-MAML1 antibody (A03990-2) and anti-Alpha Tubulin antibody (M03989-3)

Flow Cytometry analysis of Jurkat cells using anti-MAML1 antibody (A03990-2)

Human

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A03990-2
100 μg/vial

MAML1 Overview

Facts about Mastermind-like protein 1.

MAML1 3D structure. Source: alphafold

Mastermind-like protein 1 (MAML1)

Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to Boost NOTCH-induced transcription of HES1.

Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation in NOTCH enhancers and activates transcription.

Gene Information

Human
Gene Name:	MAML1
Uniprot:	Q92585
Entrez:	9794

Family

Belongs to:

mastermind family

Alternative Names

FLJ53540; KIAA0200Mam1; Mam-1mastermind homolog; mastermind (drosophila)-like 1; mastermind-like 1 (Drosophila); mastermind-like protein 1

Molecular Weight

Mass (kDA):
108.054 kDA

Genomic Context


Human

Location:	5q35.3
Sequence:	5; NC_000005.10 (179732822..179777283)

Tissue Specificity

Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen.

Subcellular Localizations

Nucleus speckle. Nuclear, in a punctate manner.

Diseases

Neoplasms
Malignant Neoplasms
Cell Transformation, Neoplastic
Leukemia
Carcinoma
Malignant Paraganglionic Neoplasm
Mammary Neoplasms
Precursor T-cell Lymphoblastic Leukemia-lymphoma
Acute Lymphocytic Leukemia
Neoplasm Metastasis
Malignant Neoplasm Of Breast
Melanoma
Tumor Angiogenesis

Cell Invasion
Lymphoma
Mucoepidermoid Carcinoma
Leukemogenesis
Neoplasm Invasiveness
Malignant Squamous Cell Neoplasm
Metastatic Malignant Neoplasm To The Lymph Node

Interacting Proteins

NOTCH1

Pathways

Notch Signaling Pathway
Cell Proliferation
Pathogenesis
Cell Growth
Angiogenesis
Proteolysis
Neurogenesis
Cell Differentiation
Localization
Cell Migration
Cell Fate Determination
Keratinocyte Differentiation
Cell Cycle

Histone Acetylation
Cell Death
Rna Interference
Cell Adhesion
Hyperphosphorylation
Regulation Of Gene Expression
Vasculogenesis

PTMs

Cleavage
Acetylation
Phosphorylation

Sumoylation
Methylation
Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAML1

References

PMID: 11101851 by Wu L., et al. MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.

PMID: 11390662 by Kitagawa M., et al. A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of Notch and a CSL protein to build a transcriptional activator complex on target promoters.