Mastermind-like protein 2 Antibodies

AND MAML2 ELISA kits, Mastermind-like protein 2 Proteins

Many biological assays use antibodies to detect Mastermind-like protein 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Mastermind-like protein 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Mastermind-like protein 2 antibodies...

We validate the specificity of these antibodies to Mastermind-like protein 2 by testing them on tissues known to express MAML2 positively and negatively. Browse below to find the MAML2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for Mastermind-like protein 2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the MAML2 IHC Guide

MAML2 Infographic by Boster Bio

All MAML2 Products

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Product

Figures

Specificity

Applications

Price

Anti-MAML2 Antibody (Center)

Human

IHC-P, WB

$299
Cat # M03679-1
80 µl

MAML2 (NM_032427) Human Over-expression Lysate

Human

$960
Cat # LS084441
20 µg, 100 µg

Anti-MAML2 Antibody Picoband®

Western blot analysis of MAML2 using anti-MAML2 antibody (A03679-1)

IHC analysis of MAML2 using anti-MAML2 antibody (A03679-1)

Human, Rat

IHC, WB

$370
Cat # A03679-1
100 μg/vial

MAML2 Overview

Facts about Mastermind-like protein 2.

MAML2 3D structure. Source: alphafold

Mastermind-like protein 2 (MAML2)

Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.

Potentiates activation by NOTCH3 and NOTCH4 Better than MAML1 or MAML3. .

Gene Information

Human
Gene Name:	MAML2
Uniprot:	Q8IZL2
Entrez:	84441

Family

Belongs to:

mastermind family

Alternative Names

DKFZp686N0150; KIAA1819MGC176701; MAM2; mam-2; MAM-3; MAM3MLL-MAML2; mastermind (Drosophila)-like 2; mastermind-like 2 (Drosophila); mastermind-like protein 2

Molecular Weight

Mass (kDA):
125.197 kDA

Genomic Context


Human

Location:	11q21
Sequence:	11; NC_000011.10 (95976598..96343308, complement)

Tissue Specificity

Widely expressed with high levels detected in placenta, salivary gland and skeletal muscle.

Subcellular Localizations

Nucleus speckle. Nuclear, in a punctate manner.

Diseases

Neoplasms
Carcinoma
Mucoepidermoid Carcinoma
Salivary Gland Neoplasms
Malignant Neoplasms
Malignant Paraganglionic Neoplasm
Adenolymphoma
Salivary Gland Diseases
Parotid Gland Warthin Tumor
Neoplasm Metastasis
Cell Transformation, Neoplastic
Chromosomal Translocation
Eccrine Acrospiroma

Adenocarcinoma
Leukemia
Clear Cell Hidradenoma
Adenoid Cystic Carcinoma
Salivary Gland Carcinoma
Acinar Cell Carcinoma
Malignant Squamous Cell Neoplasm

Pathways

Localization
Cell Cycle
Pathogenesis
Notch Signaling Pathway
Reverse Transcription
Keratinization
Cell Proliferation
Induction Of Apoptosis
Cell Development
Dna Methylation
Regulation Of Gene Expression
Response To Actinomycin D
Cell Cycle Arrest

Methylation
Senescence
Regeneration
Drug Resistance
Dna Replication
Cell Death
Liver Regeneration

PTMs

Sumoylation
Phosphorylation

Methylation
Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAML2

References

PMID: 12539049 by Tonon G., et al. t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway.

PMID: 14720503 by Enlund F., et al. Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors.