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- Table of Contents
Facts about Dual specificity mitogen-activated protein kinase kinase 2.
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Human | |
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Gene Name: | MAP2K2 |
Uniprot: | P36507 |
Entrez: | 5605 |
Belongs to: |
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protein kinase superfamily |
ERK activator kinase 2; MAP2K2; MAPKK 2; MEK 2; MEK2; MEK2EC 2.7.12.2; mitogen-activated protein kinase kinase 2; MKK2; MKK2FLJ26075; p45; PRKMK2MAPKK2
Mass (kDA):
44.424 kDA
Human | |
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Location: | 19p13.3 |
Sequence: | 19; NC_000019.10 (4090321..4124184, complement) |
Cytoplasm. Membrane; Peripheral membrane protein. Membrane localization is probably regulated by its interaction with KSR1.
Boster primary antibodies are extremely effective in IHC. Their antibodies are extremely affinity and have been validated for use in Western Blotting, Immunohistochemistry and ELISA. Boster antibodies have also been cited extensively in the research community. If you're looking for an antibody that binds to the MAP2K2 protein, you've come to the right spot.
The IHC in Boster Bio is based on a proprietary ELISA platform called PicoKine(tm) which was created by Steven Boster. The system increases the ability to detect picogram levels which can reduce IHC time by up to 30 minutes. Boster's proprietary technology is supported by Sanbio, BeNeLux's antibody distributor. PicoKine uses exclusive trade secrets to create sensitive ELISA kits that can be used for any purpose in research.
In this process, tissue samples are extracted from various sources, such as autopsy, biopsy, and animal models. However, the autopsy specimen is typically taken after the animal has passed away. This makes the sample similar to the postmortem examination. It is crucial to fix this specimen as soon as the animal dies as the antigens may denature or disappear within two hours. Boster also offers a manual on IHC sample preparation and troubleshooting of immunostaining.
Secondary antibodies are antibodies that bind to primary antibodies. The primary antibody is used to detect proteins. Boster Bio also makes secondary antibodies to perform IHC. These antibodies can bind to various conjugates. They can be classified according to molecular weight. This is a good option to determine IHC/ICC/IF. This method is very helpful in research and development. It does have its limitations.
PMID: 8388392 by Zheng C.-F., et al. Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2.
PMID: 17116858 by Mittal R., et al. Acetylation of MEK2 and I kappa B kinase (IKK) activation loop residues by YopJ inhibits signaling.