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MAP3K1 Antibodies
AND MAP3K1 ELISA kits, MAP3K1 Proteins
Many biological assays use antibodies to detect MAP3K1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAP3K1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAP3K1 antibodies...
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MAP3K1 Infographic by Boster Bio
All MAP3K1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # PA1923
100 μg/vial
Cat # PA1923
100 μg/vial
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A01972T1402
100ul
Cat # A01972T1402
100ul
MAP3K1 Overview
Facts about Mitogen-activated protein kinase kinase kinase 1.
Mitogen-activated protein kinase kinase kinase 1 (MAP3K1)
Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624).
May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the fundamental protein kinases of the NF- kappa-B pathway (PubMed:9808624).
Gene Information
| Human | |
|---|---|
| Gene Name: | MAP3K1 |
| Uniprot: | Q13233 |
| Entrez: | 4214 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
Map3k1; MAPK/ERK kinase kinase 1; MAPKKK1MAP/ERK kinase kinase 1; MEK kinase 1; MEKK1EC 2.7.11.25; MEKKMEKK 1; mitogen-activated protein kinase kinase kinase 1
Molecular Weight
Mass (kDA):
164.47 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q11.2 |
| Sequence: | 5; NC_000005.10 (56815543..56896152) |
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Carcinoma
- Tissue Adhesions
- Inflammation
- Leukemia
- Neoplasm Metastasis
- Tumor Angiogenesis
- Malignant Paraganglionic Neoplasm
- Cell Invasion
Interacting Proteins
- ARRB2
- BRAF
- DCAF7
- FLNB
- MAP2K4
- MAP4K2
- TRAF2
Pathways
- Cell Death
- Cell Proliferation
- Cell Cycle
- Cell Growth
- Secretion
- Induction Of Apoptosis
- Angiogenesis
- Localization
- Cell Migration
- Pathogenesis
- Cell Differentiation
- Cell Adhesion
- Cell Cycle Arrest
PTMs
- Phosphorylation
- Cleavage
- Ubiquitination
- Dephosphorylation
- Sumoylation
Research Areas
- Angiogenesis
- Breast Cancer
- Cancer
- Lipid and Metabolism
- MAP Kinase Signaling
- mTOR Pathway
- Protein Kinase
- Signal Transduction
- Tyrosine Kinases
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAP3K1
bosterbio.com/bosterbio-gene-info-cards/MAP3K1
References
PMID: 9808624 by Xia Y., et al. JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension.
PMID: 8597633 by Vinik B.S., et al. Mapping of the MEK kinase gene (Mekk) to mouse chromosome 13 and human chromosome 5.
1 Publications of Boster MAP3K1 Antibodies & ELISA Kits
- PubMed ID: -, MiRNA-let-7b decreases proliferation activities and development of follicular ce...
*More publications can be found for each product on its corresponding product page