MAP3K4 Antibodies

AND MAP3K4 ELISA kits, MAP3K4 Proteins

Many biological assays use antibodies to detect MAP3K4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAP3K4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAP3K4 antibodies...

We validate the specificity of these antibodies to MAP3K4 by testing them on tissues known to express MAP3K4 positively and negatively. Browse below to find the MAP3K4 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for MAP3K4? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the MAP3K4 IHC Guide

MAP3K4 Infographic by Boster Bio

All MAP3K4 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-MAP3K4 Rabbit Monoclonal Antibody

Western blot analysis of MAP3K4 using anti-MAP3K4 antibody (M04842)

Human

IHC, WB

$370
Cat # M04842
100 μl/vial

MAP3K4 (NM_005922) Human Over-expression Lysate

Human

$960
Cat # LS004216
20 µg, 100 µg

Anti-MAP3K4/Mekk4 Antibody

Immunohistochemistry analysis of paraffin-embedded human heart tissue, using MAP3K4 Antibody

Human, Mouse

ELISA, IF, IHC, ICC

$335
Cat # A04842
100ul

MAP3K4 Overview

Facts about Mitogen-activated protein kinase kinase kinase 4.

MAP3K4 3D structure. Source: alphafold

Mitogen-activated protein kinase kinase kinase 4 (MAP3K4)

Part of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway.

Specifically phosphorylates and activates MAP2K4 and MAP2K6. .

Gene Information

Human
Gene Name:	MAP3K4
Uniprot:	Q9Y6R4
Entrez:	4216

Family

Belongs to:

protein kinase superfamily

Alternative Names

EC 2.7.11.25; FLJ42439; MAPKKK4yeast, homolog of; MEKK 4; mitogen-activated protein kinase kinase kinase 4

Molecular Weight

Mass (kDA):
181.685 kDA

Genomic Context


Human

Location:	6q26
Sequence:	6; NC_000006.12 (160991521..161117385)

Tissue Specificity

Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in other tissues.

Subcellular Localizations

Cytoplasm, perinuclear region. Localized in perinuclear vesicular-like structures, probably Golgi-associated vesicles.

Diseases

Malignant Neoplasms
Neoplasms
Carcinoma
Embryonal Carcinoma
Malignant Neoplasm Of Breast
Mammary Neoplasms
Tobacco Use Disorder
Ovarian Neoplasm
Genomic Instability
Physiological Stress
Nicotine Dependence
Crohn Disease

Inflammation
Malignant Neoplasm Of Ovary
Cell Transformation, Neoplastic
Neoplasm Metastasis
Malnutrition
Ataxia
Hypoxia

Interacting Proteins

FLNB
GADD45B
MAP2K6
SH3KBP1
UBC

Pathways

Neural Tube Closure
Cellular Homeostasis
Sex Determination
Cell Proliferation
Tube Closure
Pathogenesis
Transport
Cell Migration
Regulation Of Signal Transduction
Immune Response
Spermatogenesis
Nuclear Transport
Inflammatory Response

Translation
Cell Cycle
Histone Acetylation
Meiosis
Endoderm Formation
Apoptotic Signaling Pathway
Jnk Cascade

PTMs

Phosphorylation

Sumoylation

Acetylation

Research Areas

Angiogenesis
Cancer
Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAP3K4

References

PMID: 9305639 by Takekawa M., et al. A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways.

PMID: 12052864 by Mita H., et al. Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding.