Mitogen-activated protein kinase kinase kinase 13 (MAP3K13)

Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7.

Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol.

This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. .