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- Table of Contents
Facts about Mitogen-activated protein kinase kinase kinase 13.
Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7.
Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol.This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. .
Human | |
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Gene Name: | MAP3K13 |
Uniprot: | O43283 |
Entrez: | 9175 |
Belongs to: |
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protein kinase superfamily |
EC 2.7.11; EC 2.7.11.25; Leucine zipper-bearing kinase; LZKMGC133196; MEKK13; mitogen-activated protein kinase kinase kinase 13; Mixed lineage kinase; MLK
Mass (kDA):
108.296 kDA
Human | |
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Location: | 3q27.2 |
Sequence: | 3; NC_000003.12 (185282938..185489094) |
Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas.
Cytoplasm. Membrane; Peripheral membrane protein.
PMID: 9353328 by Sakuma H., et al. Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain.
PMID: 8274451 by Schultz S.J., et al. Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.