MARCHF1 Antibodies

AND MARCHF1 ELISA kits, MARCHF1 Proteins

Many biological assays use antibodies to detect MARCHF1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MARCHF1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MARCHF1 antibodies...

We validate the specificity of these antibodies to MARCHF1 by testing them on tissues known to express MARCHF1 positively and negatively. Browse below to find the MARCHF1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MARCHF1 Infographic by Boster Bio

All MARCHF1 Products

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RNF190 (MARCH10) (NM_152598) Human Over-expression Lysate

RNF190 (MARCH10) Human Over-expression Lysates NM_001100875

Human

$628
Cat # LS162333
20 µg, 100 µg

MARCHF1 Overview

Facts about E3 ubiquitin-protein ligase MARCHF1.

MARCHF1 3D structure. Source: alphafold

E3 ubiquitin-protein ligase MARCHF1 (MARCHF1)

E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and boosts their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system.

Gene Information

Human
Gene Name:	MARCHF1
Uniprot:	Q8TCQ1
Entrez:	55016

Family

Belongs to:

No superfamily

Alternative Names

E3 ubiquitin-protein ligase MARCHF1

Molecular Weight

Mass (kDA):
32.308 kDA

Genomic Context


Human

Location:	4q32.2-q32.3
Sequence:	4; NC_000004.12 (163524298..164384050, complement)

Tissue Specificity

Expressed in antigen presenting cells, APCs, located in lymph nodes and spleen. Also expressed in lung. Expression is high in follicular B-cells, moderate in dendritic cells and low in splenic T-cells.

Subcellular Localizations

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MARCHF1

References

PMID: 14722266 by Bartee E., et al. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins.

PMID: 17255932 by Matsuki Y., et al. Novel regulation of MHC class II function in B cells.