MARCHF5 Antibodies

AND MARCHF5 ELISA kits, MARCHF5 Proteins

Many biological assays use antibodies to detect MARCHF5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MARCHF5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MARCHF5 antibodies...

We validate the specificity of these antibodies to MARCHF5 by testing them on tissues known to express MARCHF5 positively and negatively. Browse below to find the MARCHF5 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MARCHF5 Infographic by Boster Bio

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MARCHF5 (NM_017824) Human Over-expression Lysate

Human

$628
Cat # LS054708
20 µg, 100 µg

MARCHF5 Overview

Facts about E3 ubiquitin-protein ligase MARCHF5.

MARCHF5 3D structure. Source: alphafold

E3 ubiquitin-protein ligase MARCHF5 (MARCHF5)

Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control.

Promotes ubiquitination of FIS1, DNM1L and MFN1. .

Gene Information

Human
Gene Name:	MARCHF5
Uniprot:	Q9NX47
Entrez:	54708

Family

Belongs to:

No superfamily

Alternative Names

E3 ubiquitin-protein ligase MARCHF5

Molecular Weight

Mass (kDA):
31.232 kDA

Genomic Context


Human

Location:	10q23.32-q23.33
Sequence:	10; NC_000010.11 (92291164..92353964)

Tissue Specificity

Expressed in brain, heart, liver, lung, spleen, stomach, testis, skeletal and muscle.

Subcellular Localizations

Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Authors show that the protein can be detected in endoplasmic reticulum (PubMed:14722266). Authors (PubMed:16874301) show its presence only in mitochondria (PubMed:16874301).

Interacting Proteins

DENR
FATE1
MFN2
UBC
UBE2W

PTMs

Ubl conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MARCHF5

References

PMID: 16936636 by Nakamura N., et al. MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology.

PMID: 14722266 by Bartee E., et al. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins.