MARCHF6 Antibodies

AND MARCHF6 ELISA kits, MARCHF6 Proteins

Many biological assays use antibodies to detect MARCHF6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MARCHF6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MARCHF6 antibodies...

We validate the specificity of these antibodies to MARCHF6 by testing them on tissues known to express MARCHF6 positively and negatively. Browse below to find the MARCHF6 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MARCHF6 Infographic by Boster Bio

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MARCHF6 Overview

Facts about E3 ubiquitin-protein ligase MARCHF6.

MARCHF6 3D structure. Source: alphafold

E3 ubiquitin-protein ligase MARCHF6 (MARCHF6)

E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

May collaborate with UBE2G1. .

Gene Information

Human
Gene Name:	MARCHF6
Uniprot:	O60337
Entrez:	10299

Family

Belongs to:

No superfamily

Alternative Names

E3 ubiquitin-protein ligase MARCH6; EC 6.3.2.-; MARCH-VIDOA10; membrane-associated ring finger (C3HC4) 6; Membrane-associated RING finger protein 6; Membrane-associated RING-CH protein VI; Protein TEB-4; RNF176KIAA0597Doa10 homolog; TEB4RING finger protein 176

Molecular Weight

Mass (kDA):
102.545 kDA

Genomic Context


Human

Location:	5p15.2
Sequence:	5; NC_000005.10 (10353693..10440388)

Tissue Specificity

Present in brain (at protein level).

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

Cholestasis
Diabetes Mellitus, Non-insulin-dependent
Progressive Intrahepatic Cholestasis (disorder)
Intrahepatic Cholestasis
Neoplasms
Obesity

Pathways

Pathogenesis
Transport
Secretory Pathway
Membrane Organization
Glycosylation
Rna Interference

PTMs

Ubiquitination

Glycosylation

Research Areas

Zinc Finger

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MARCHF6

References

PMID: 11641273 by Swanson R., et al. A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation.

PMID: 15673284 by Hassink G., et al. TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum.