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- Table of Contents
MBD1 Antibodies
AND MBD1 ELISA kits, MBD1 Proteins
Many biological assays use antibodies to detect MBD1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MBD1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MBD1 antibodies...
Designing a Western blot for MBD1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MBD1 Western Blot GuideMBD1 Infographic by Boster Bio
All MBD1 Products
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MBD1 Overview
Facts about Methyl-CpG-binding domain protein 1.
Methyl-CpG-binding domain protein 1 (MBD1)
Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that's made by DNA damage by methylmethanesulfonate (MMS).
Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which subsequently recruits factors like the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone'Lys-9' trimethylation.
Gene Information
| Human | |
|---|---|
| Gene Name: | MBD1 |
| Uniprot: | Q9UIS9 |
| Entrez: | 4152 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CXXC-type zinc finger protein 3; methyl-CpG binding domain protein 1 isoform PCM1; methyl-CpG binding domain protein 1; methyl-CpG-binding domain protein 1; Methyl-CpG-binding protein MBD1; PCM1CXXC3RFT; Protein containing methyl-CpG-binding domain 1; the regulator of fibroblast growth factor 2 (FGF-2) transcription
Molecular Weight
Mass (kDA):
66.607 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18q21.1 |
| Sequence: | 18; NC_000018.10 (50266882..50281774, complement) |
Tissue Specificity
Widely expressed.
Subcellular Localizations
Nucleus. Nucleus matrix. Nucleus speckle. Chromosome. Colocalizes with the Ten-1 ICD form of TENM1 in foci associated with the nuclear matrix (By similarity). Nuclear, in a punctate pattern. Associated with euchromatic regions of the chromosomes, with pericentromeric regions on chromosome 1 and with telomeric regions from several chromosomes.
Diseases
- Metabolic Bone Disorder
- Malignant Neoplasms
- Neoplasms
- Rett Syndrome
- Carcinoma
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Lung
- Lung Neoplasms
- Malignant Neoplasm Of Breast
- Prostatic Neoplasms
- Autistic Disorder
- Carcinogenesis
Interacting Proteins
- CBX5
- CHAF1A
- HDAC1
- HDAC2
- HDAC3
- HTT
- PIAS1
- PIAS3
- SETDB1
- SUMO1
Pathways
- Methylation
- Dna Methylation
- Gene Silencing
- Localization
- Demethylation
- Rna Interference
- Histone Modification
- Regulation Of Gene Expression
- Cell Differentiation
- Histone Acetylation
- Histone Methylation
- Chromatin Remodeling
- Histone Deacetylation
PTMs
- Methylation
- Acetylation
- Deacetylation
- Demethylation
- Phosphorylation
Research Areas
- Chromatin Research
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MBD1
bosterbio.com/bosterbio-gene-info-cards/MBD1
References
PMID: 9207790 by Cross S.H., et al. A component of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteins.
PMID: 10441743 by Hendrich B., et al. Genomic structure and chromosomal mapping of the murine and human mbd1, mbd2, mbd3, and mbd4 genes.