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- Table of Contents
Melanocortin receptor 4 Antibodies
AND MC4R ELISA kits, Melanocortin receptor 4 Proteins
Many biological assays use antibodies to detect Melanocortin receptor 4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Melanocortin receptor 4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Melanocortin receptor 4 antibodies...
Designing a Western blot for Melanocortin receptor 4? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MC4R Western Blot GuideDesigning an IHC experiment for Melanocortin receptor 4? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the MC4R IHC GuideMC4R Infographic by Boster Bio
All MC4R Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00619-2
100 μg/vial
Cat # A00619-2
100 μg/vial
Human, Mouse, Rat
ELISA, IF, IHC-P, WB
$481
Cat # A00619
0.1 mg
Cat # A00619
0.1 mg
MC4R Overview
Facts about Melanocortin receptor 4.
Melanocortin receptor 4 (MC4R)
Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth.
This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). .
Gene Information
| Human | |
|---|---|
| Gene Name: | MC4R |
| Uniprot: | P32245 |
| Entrez: | 4160 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
Fatboy; Glu3; MC4R; MC4-R; melanocortin 4 receptor; melanocortin receptor 4; Melanocortin-4 R; Melanocortin4R; Melanocortin-4R; MGC126851; MGC138197
Molecular Weight
Mass (kDA):
36.943 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18q21.32 |
| Sequence: | 18; NC_000018.10 (60371062..60372775, complement) |
Tissue Specificity
Brain, placental, and gut tissues.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Obesity
- Diabetes Mellitus
- Hyperphagia
- Diabetes Mellitus, Non-insulin-dependent
- Nervousness
- Pediatric Obesity
- Insulin Resistance
- Obesity, Morbid
- Hypertensive Disease
- Hyperinsulinism
- Malignant Neoplasms
- Cachexia
Interacting Proteins
- MRAP
Pathways
- Energy Homeostasis
- Feeding Behavior
- Pigmentation
- Regulation Of Energy Homeostasis
- Localization
- Secretion
- Pathogenesis
- Eating Behavior
- Inflammatory Response
- Glucose Homeostasis
- Regulation Of Appetite
- Transport
- Insulin Secretion
PTMs
- Phosphorylation
- Cleavage
- Oxidation
- Acetylation
- Methylation
Research Areas
- GPCR
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MC4R
bosterbio.com/bosterbio-gene-info-cards/MC4R
References
PMID: 8392067 by Gantz I., et al. Molecular cloning, expression, and gene localization of a fourth melanocortin receptor.
PMID: 7854347 by Mountjoy K.G., et al. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.