Melanocortin receptor 4 Antibodies

AND MC4R ELISA kits, Melanocortin receptor 4 Proteins

Many biological assays use antibodies to detect Melanocortin receptor 4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Melanocortin receptor 4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Melanocortin receptor 4 antibodies...

We validate the specificity of these antibodies to Melanocortin receptor 4 by testing them on tissues known to express MC4R positively and negatively. Browse below to find the MC4R antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MC4R Infographic by Boster Bio

All MC4R Products

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Anti-MC4-R/MC4R Antibody Picoband®

Western blot analysis of MC4R using anti-MC4R antibody (A00619-2)

IHC analysis of MC4R using anti-MC4R antibody (A00619-2)

IF analysis of MC4R using anti-MC4R antibody (A00619-2)

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A00619-2
100 μg/vial

Anti-Melanocortin receptor 4 MC4R Antibody

Western blot analysis of MC4R in rat brain tissue lysate with MC4R antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide

Immunofluorescence of MC4R in Human Brain cells with MC4R antibody at 20 μg/mL

Immunohistochemistry of MC4R in human brain tissue with MC4R antibody at 2

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$481
Cat # A00619
0.1 mg

Anti-MC4 Receptor Rabbit Monoclonal Antibody

Western blot analysis of MC4 Receptor expression in (1) MCF7 cell lysate; (2) RAW264

Human, Mouse, Rat

$370
Cat # M00619
100 μl/vial

MC4 Receptor (MC4R) (NM_005912) Human Over-expression Lysate

Human

$628
Cat # LS004160
20 µg, 100 µg

Anti-Zebrafish MC4R Antibody Picoband®

Western blot analysis of MC4R using anti-MC4R antibody (AZB0V1P1)

IHC analysis of MC4R using anti-MC4R antibody (AZB0V1P1)

Zebrafish

IHC, WB

$470
Cat # AZB0V1P1
100 μg/vial

MC4R Overview

Facts about Melanocortin receptor 4.

MC4R 3D structure. Source: alphafold

Melanocortin receptor 4 (MC4R)

Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth.

This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). .

Gene Information

Human
Gene Name:	MC4R
Uniprot:	P32245
Entrez:	4160

Family

Belongs to:

G-protein coupled receptor 1 family

Alternative Names

Fatboy; Glu3; MC4R; MC4-R; melanocortin 4 receptor; melanocortin receptor 4; Melanocortin-4 R; Melanocortin4R; Melanocortin-4R; MGC126851; MGC138197

Molecular Weight

Mass (kDA):
36.943 kDA

Genomic Context


Human

Location:	18q21.32
Sequence:	18; NC_000018.10 (60371062..60372775, complement)

Tissue Specificity

Brain, placental, and gut tissues.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Diseases

Obesity
Diabetes Mellitus
Hyperphagia
Diabetes Mellitus, Non-insulin-dependent
Nervousness
Pediatric Obesity
Insulin Resistance
Obesity, Morbid
Hypertensive Disease
Hyperinsulinism
Malignant Neoplasms
Cachexia

Dysequilibrium Syndrome
Pituitary Diseases
Inflammation
Eating Disorders
Insulin Sensitivity
Haploinsufficiency

Interacting Proteins

MRAP

Pathways

Energy Homeostasis
Feeding Behavior
Pigmentation
Regulation Of Energy Homeostasis
Localization
Secretion
Pathogenesis
Eating Behavior
Inflammatory Response
Glucose Homeostasis
Regulation Of Appetite
Transport
Insulin Secretion

Endocytosis
Lactation
Excretion
Immune Response
Reverse Transcription
Translation
Regulation Of Feeding Behavior

PTMs

Phosphorylation
Cleavage
Oxidation
Acetylation
Methylation

Acylation
Ubiquitination
Carboxylation
Glycosylation
Amidation

Iodination

Research Areas

GPCR
Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MC4R

References

PMID: 8392067 by Gantz I., et al. Molecular cloning, expression, and gene localization of a fourth melanocortin receptor.

PMID: 7854347 by Mountjoy K.G., et al. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.