MCC Antibodies

AND MCC ELISA kits, MCC Proteins

Many biological assays use antibodies to detect MCC, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MCC in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MCC antibodies...

We validate the specificity of these antibodies to MCC by testing them on tissues known to express MCC positively and negatively. Browse below to find the MCC antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MCC Infographic by Boster Bio

All MCC Products

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Figures

Specificity

Applications

Price

MCC (NM_002387) Human Recombinant Protein

Coomassie blue staining of purified MCC protein

$1249
Cat # PROTP23508
20 µg

Anti-MCC Antibody Picoband®

Western blot analysis of MCC using anti-MCC antibody (A00711-1)

Flow Cytometry analysis of Hela cells using anti-MCC antibody (A00711-1)

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A00711-1
100 μg/vial

MCC (NM_002387) Human Over-expression Lysate

Human

$628
Cat # LS004163
20 µg, 100 µg

MCC Overview

Facts about Colorectal mutant cancer protein.

MCC 3D structure. Source: alphafold

Colorectal mutant cancer protein (MCC)

Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation as well as the Wnt/b- catenin pathway in colorectal cancer cells.

Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440).

Gene Information

Human
Gene Name:	MCC
Uniprot:	P23508
Entrez:	4163

Family

Belongs to:

MCC family

Alternative Names

colorectal mutant cancer protein; DKFZp762O1615; FLJ38893; FLJ46755; MCC1; mutated in colorectal cancers; Protein MCC

Molecular Weight

Mass (kDA):
93.027 kDA

Genomic Context


Human

Location:	5q22.2
Sequence:	5; NC_000005.10 (113022101..113488453, complement)

Tissue Specificity

Expressed in a variety of tissues.

Subcellular Localizations

Cell membrane. Cell projection, lamellipodium. Nucleus. Cytoplasm. Colocalizes with actin at the leading edge of polarized cells.

Diseases

Neoplasms
Carcinoma
Malignant Neoplasms
Merkel Cell Carcinoma
Skin Neoplasms
Colorectal Cancer
Neoplasm Metastasis
Colorectal Neoplasms
Adenomatous Polyposis Coli
Polyposis
Malignant Paraganglionic Neoplasm
Carcinogenesis
Cell Transformation, Neoplastic

Adenocarcinoma
Malignant Neoplasm Of Skin
Pain
Malignant Squamous Cell Neoplasm
Malignant Neoplasm Of Lung
Inflammation
Polyomavirus Infections

Interacting Proteins

CSNK1E
GTF2E2
PTPN3
SCRIB

Pathways

Pathogenesis
Transport
Localization
Anaphase
Secretion
Cell Cycle
Excretion
Immune Response
Mitosis
Cell Proliferation
Methylation
Cell Growth
Spindle Assembly

Chromosome Segregation
Spindle Checkpoint
Protein Import
Cell Differentiation
Segmentation
Dna Methylation
Translation

PTMs

Phosphorylation
Methylation
Ubiquitination
Oxidation
Cleavage
Nitration

Biotinylation
Reduction
Acetylation
Carboxylation
Acylation
Prenylation

Glycosylation

Research Areas

Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MCC

References

PMID: 1848370 by Kinzler K.W., et al. Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers.

PMID: 18591935 by Fukuyama R., et al. Mutated in colorectal cancer, a putative tumor suppressor for serrated colorectal cancer, selectively represses beta-catenin- dependent transcription.