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- Table of Contents
MCC Antibodies
AND MCC ELISA kits, MCC Proteins
Many biological assays use antibodies to detect MCC, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MCC in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MCC antibodies...
Designing a Western blot for MCC? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MCC Western Blot GuideMCC Infographic by Boster Bio
All MCC Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A06515-2
100 µg/vial
Cat # A06515-2
100 µg/vial
Human, Mouse, Rat
ELISA, IF, IHC, ICC, WB
$370
Cat # A07441-1
100 µg/vial
Cat # A07441-1
100 µg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00711-1
100 μg/vial
Cat # A00711-1
100 μg/vial
MCC Overview
Facts about Colorectal mutant cancer protein.
Colorectal mutant cancer protein (MCC)
Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation as well as the Wnt/b- catenin pathway in colorectal cancer cells.
Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440).
Gene Information
| Human | |
|---|---|
| Gene Name: | MCC |
| Uniprot: | P23508 |
| Entrez: | 4163 |
Family
| Belongs to: |
|---|
| MCC family |
Alternative Names
colorectal mutant cancer protein; DKFZp762O1615; FLJ38893; FLJ46755; MCC1; mutated in colorectal cancers; Protein MCC
Molecular Weight
Mass (kDA):
93.027 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q22.2 |
| Sequence: | 5; NC_000005.10 (113022101..113488453, complement) |
Tissue Specificity
Expressed in a variety of tissues.
Subcellular Localizations
Cell membrane. Cell projection, lamellipodium. Nucleus. Cytoplasm. Colocalizes with actin at the leading edge of polarized cells.
Diseases
- Neoplasms
- Carcinoma
- Malignant Neoplasms
- Merkel Cell Carcinoma
- Skin Neoplasms
- Colorectal Cancer
- Neoplasm Metastasis
- Colorectal Neoplasms
- Adenomatous Polyposis Coli
- Polyposis
- Malignant Paraganglionic Neoplasm
- Carcinogenesis
- Cell Transformation, Neoplastic
Interacting Proteins
- CSNK1E
- GTF2E2
- PTPN3
- SCRIB
Pathways
- Pathogenesis
- Transport
- Localization
- Anaphase
- Secretion
- Cell Cycle
- Excretion
- Immune Response
- Mitosis
- Cell Proliferation
- Methylation
- Cell Growth
- Spindle Assembly
PTMs
- Phosphorylation
- Methylation
- Ubiquitination
- Oxidation
- Cleavage
- Nitration
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MCC
bosterbio.com/bosterbio-gene-info-cards/MCC
References
PMID: 1848370 by Kinzler K.W., et al. Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers.
PMID: 18591935 by Fukuyama R., et al. Mutated in colorectal cancer, a putative tumor suppressor for serrated colorectal cancer, selectively represses beta-catenin- dependent transcription.