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MCFD2 Antibodies
AND MCFD2 ELISA kits, MCFD2 Proteins
Many biological assays use antibodies to detect MCFD2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MCFD2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MCFD2 antibodies...
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MCFD2 Infographic by Boster Bio
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MCFD2 Overview
Facts about Multiple coagulation factor deficiency protein 2.
Multiple coagulation factor deficiency protein 2 (MCFD2)
The MCFD2-LMAN1 complex forms a particular cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors.
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Gene Information
| Human | |
|---|---|
| Gene Name: | MCFD2 |
| Uniprot: | Q8NI22 |
| Entrez: | 90411 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
DKFZp686G21263; F5F8D2; LMAN1IP; MCFD2; multiple coagulation factor deficiency 2; multiple coagulation factor deficiency protein 2; neural stem cell derived neuronal survival protein; Neural stem cell-derived neuronal survival protein; SDNSF; SDNSFF5F8D
Molecular Weight
Mass (kDA):
16.39 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p21 |
| Sequence: | 2; NC_000002.12 (46901870..46941855, complement) |
Subcellular Localizations
Endoplasmic reticulum-Golgi intermediate compartment. Endoplasmic reticulum. Golgi apparatus.
Diseases
- Factor V Deficiency
- Hemophilia A
- Hemorrhage
- Bleeding Tendency
- Coagulation Factor Deficiency
- Blood Coagulation Disorders
- Familial Multiple Factor Deficiency Syndrome, Type I
- Blood Coagulation Disorders, Inherited
- Contusions
- Hereditary Diseases
- Pregnancy Complications, Hematologic
- Brain Ischemia
Interacting Proteins
- LMAN1
Pathways
- Transport
- Coagulation
- Secretory Pathway
- Secretion
- Intracellular Transport
- Blood Coagulation
- Protein Folding
- Hemostasis
- Response To Stress
- Proteolysis
- Glycosylation
- Neurogenesis
- Protein Secretion
PTMs
- Biotinylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MCFD2
bosterbio.com/bosterbio-gene-info-cards/MCFD2
References
PMID: 12717434 by Zhang B., et al. Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex.
PMID: 18590741 by Guy J.E., et al. New insights into multiple coagulation factor deficiency from the solution structure of human MCFD2.