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- Table of Contents
MCL1 Antibodies
AND MCL1 ELISA kits, MCL1 Proteins
Many biological assays use antibodies to detect MCL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MCL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MCL1 antibodies...
Designing a Western blot for MCL1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MCL1 Western Blot GuideMCL1 Infographic by Boster Bio
All MCL1 Products
Product
Figures
Specificity
Applications
Price
Anti-MCL1 Rabbit Monoclonal Antibody
1 Citations
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00712
100 μl
Cat # M00712
100 μl
Human
Flow Cytometry, IF, IHC, WB
$523
Cat # M00712-1
100 µl
Cat # M00712-1
100 µl
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A00712-2
100 µg/vial
Cat # A00712-2
100 µg/vial
MCL1 Colorimetric Cell-Based ELISA Kit
1 Citations
Human, Mouse, Rat
ELISA
$480
Cat # EKC1353
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1353
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
Flow Cytometry, IHC-P, WB
$299
Cat # A00712-1
80 µl
Cat # A00712-1
80 µl
MCL1 Overview
Facts about Induced myeloid leukemia cell differentiation protein Mcl-1.
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with several other regulators of apoptosis.
Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
Gene Information
| Human | |
|---|---|
| Gene Name: | MCL1 |
| Uniprot: | Q07820 |
| Entrez: | 4170 |
Family
| Belongs to: |
|---|
| Bcl-2 family |
Alternative Names
BCL2L3; bcl2-L-3; BCL2L3MGC104264; Bcl-2-like protein 3; Bcl-2-related protein EAT/mcl1; EAT; induced myeloid leukemia cell differentiation protein Mcl-1; Mcl1; Mcl-1; mcl1/EAT; MCL1-ES; MCL1L; MCL1S; MGC1839; myeloid cell leukemia ES; myeloid cell leukemia sequence 1 (BCL2-related); TM
Molecular Weight
Mass (kDA):
37.337 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q21.2 |
| Sequence: | 1; NC_000001.11 (150574551..150579738, complement) |
Subcellular Localizations
Membrane; Single-pass membrane protein. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Cytoplasmic, associated with mitochondria.
Diseases
- Malignant Neoplasms
- Leukemia
- Neoplasms
- Lymphoma
- Chronic Lymphocytic Leukemia
- Myeloid Leukemia
- Lymphoid Leukemia
- Multiple Myeloma
- Cell Transformation, Neoplastic
- Carcinoma
- Leukemia, Myelocytic, Acute
- B-cell Lymphomas
- Acute Lymphocytic Leukemia
Interacting Proteins
- BAK1
- BAX
- BBC3
- BCL2L11
- BECN1
- BID
- CAV1
- Cav1
- HUWE1
- PMAIP1
Pathways
- Cell Death
- Cell Cycle
- Pathogenesis
- Cell Proliferation
- Cell Differentiation
- Induction Of Apoptosis
- Cell Cycle Arrest
- Translation
- Programmed Cell Death
- Localization
- Drug Resistance
- Rna Interference
- Angiogenesis
PTMs
- Phosphorylation
- Cleavage
- Acetylation
- Dephosphorylation
Research Areas
- Apoptosis
- Cancer
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MCL1
bosterbio.com/bosterbio-gene-info-cards/MCL1
References
PMID: 7682708 by Kozopas K.M., et al. MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2.
PMID: 8790944 by Umezawa A., et al. Induction of mcl1/EAT, Bcl-2 related gene, by retinoic acid or heat shock in the human embryonal carcinoma cells, NCR-G3.
2 Publications of Boster MCL1 Antibodies & ELISA Kits
- PubMed ID: 32951326, Zhang L,Zhang J,Gong Y,Lv L.Systematic and experimental investigations of the an...
- PubMed ID: 25747387, Liu N, Chen T, Wang X, Yang D, Xue B, Zhu H. Febs Lett. 2015 Apr 2;589(8):897-90...
*More publications can be found for each product on its corresponding product page