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Protein MCM10 homolog Antibodies
AND MCM10 ELISA kits, Protein MCM10 homolog Proteins
Many biological assays use antibodies to detect Protein MCM10 homolog, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein MCM10 homolog in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein MCM10 homolog antibodies...
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MCM10 Overview
Facts about Protein MCM10 homolog.
Protein MCM10 homolog (MCM10)
Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complicated so as to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication.
Key effector of this RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359). .
Gene Information
| Human | |
|---|---|
| Gene Name: | MCM10 |
| Uniprot: | Q7L590 |
| Entrez: | 55388 |
Family
| Belongs to: |
|---|
| MCM10 family |
Alternative Names
CNA43homolog of yeast MCM10; DNA43; hsMCM10; MCM10 minichromosome maintenance deficient 10 (S. cerevisiae); MCM10 minichromosome maintenance deficient 10; MGC126776; minichromosome maintenance complex component 10; PRO2249; protein MCM10 homolog
Molecular Weight
Mass (kDA):
98.183 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10p13 |
| Sequence: | 10; NC_000010.11 (13161558..13211110) |
Subcellular Localizations
Nucleus. Colocalizes with ORC2 in nuclei foci. Associated with chromatin in S phase. From early to mid-S phase located in discrete nuclear foci. In early S phase, several hundred foci appeared throughout the nucleus. In mid-S phase, the foci appeared at the nuclear periphery and nucleolar regions. In the late S and G phases localized to nucleoli.
Diseases
- Malignant Neoplasms
- Genomic Instability
- Cell Transformation, Neoplastic
- Physiological Stress
- Neoplasms
- Growth Arrest
- Neuroblastoma
- Endoreduplication
- Salivary Gland Diseases
- Malignant Neoplasm Of Breast
- Malignant Tumor Of Colon
- Bone Neoplasms
- Suppressor Mutation
Interacting Proteins
- GOLGA2
- KLHL40
- MCM6
- ORC2
Pathways
- Dna Replication
- Cell Cycle
- S Phase
- Cell Proliferation
- Localization
- Dna Replication Initiation
- Proteolysis
- Sister Chromatid Cohesion
- Mitosis
- G1 Phase
- Cell Death
- M Phase
- Cell Cycle Arrest
PTMs
- Phosphorylation
- Cleavage
- Ubiquitination
Research Areas
- DNA Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MCM10
bosterbio.com/bosterbio-gene-info-cards/MCM10
References
PMID: 11095689 by Izumi M., et al. The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase.
PMID: 11602595 by Izumi M., et al. Cell cycle-dependent proteolysis and phosphorylation of human Mcm10.