DNA replication licensing factor MCM4 (MCM4)

Acts as component of this MCM2-7 complex (MCM complex) that is the putative replicative helicase essential for'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring have been formed through the interaction surfaces of two neighboring subunits such a crucial structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding website of the Walker A box of the adjacent subunit.

The six ATPase active sites, however, will likely contribute differentially to the complex helicase activity. .