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- Table of Contents
Microcephalin Antibodies
AND MCPH1 ELISA kits, Microcephalin Proteins
Many biological assays use antibodies to detect Microcephalin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Microcephalin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Microcephalin antibodies...
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MCPH1 Infographic by Boster Bio
All MCPH1 Products
Product
Figures
Specificity
Applications
Price
Human
IHC, WB
$523
Cat # M02666
100 µl
Cat # M02666
100 µl
Human, Mouse
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A02666-2
100 μg/vial
Cat # A02666-2
100 μg/vial
MCPH1 Overview
Facts about Microcephalin.
Microcephalin (MCPH1)
Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | MCPH1 |
| Uniprot: | Q8NEM0 |
| Entrez: | 79648 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BRCT-repeat inhibitor of TERT expression 1; BRIT1; FLJ12847; MCPH1; MCT; microcephalin 1; Microcephalin; microcephaly, primary autosomal recessive 1
Molecular Weight
Mass (kDA):
92.849 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p23.1 |
| Sequence: | 8; NC_000008.11 (6406592..6648508) |
Tissue Specificity
Expressed in fetal brain, liver and kidney.
Subcellular Localizations
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Diseases
- Microcephaly
- Primary Microcephaly
- Neoplasms
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Genomic Instability
- Dwarfism
- Mammary Neoplasms
- Ataxia
- Ataxia Telangiectasia
- Cytogenetic Abnormality
- Autistic Disorder
Interacting Proteins
- E2F1
- TERF2
Pathways
- Cell Cycle
- Mitosis
- Chromosome Condensation
- Brain Development
- Dna Repair
- Neurogenesis
- Localization
- Cell Cycle Checkpoint
- Cell Division
- G2 Phase
- Regulation Of Chromosome Condensation
- Cognition
- Chromatin Remodeling
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MCPH1
bosterbio.com/bosterbio-gene-info-cards/MCPH1
References
PMID: 12046007 by Jackson A.P., et al. Identification of microcephalin, a protein implicated in determining the size of the human brain.
PMID: 15199523 by Trimborn M., et al. Mutations in microcephalin cause aberrant regulation of chromosome condensation.