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MyoD family inhibitor Antibodies
AND MDFI ELISA kits, MyoD family inhibitor Proteins
Many biological assays use antibodies to detect MyoD family inhibitor, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MyoD family inhibitor in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MyoD family inhibitor antibodies...
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MDFI Overview
Facts about MyoD family inhibitor.
MyoD family inhibitor (MDFI)
Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals.
Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation.
Gene Information
| Human | |
|---|---|
| Gene Name: | MDFI |
| Uniprot: | Q99750 |
| Entrez: | 4188 |
Family
| Belongs to: |
|---|
| MDFI family |
Alternative Names
I-MF; I-mfa; inhibitor of MyoD family a; MyoD family inhibitor; Myogenic repressor I-mf
Molecular Weight
Mass (kDA):
25.029 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p21.1 |
| Sequence: | 6; NC_000006.12 (41637018..41654246) |
Subcellular Localizations
Nucleus. Cytoplasm.
Diseases
- Immunologic Deficiency Syndromes
- Hiv Infections
- Leukemia, T-cell
- Carcinoma
- Malignant Neoplasms
- Neoplasms
- Pancreatic Neoplasm
- Malignant Neoplasm Of Pancreas
- Leukemia
- Non-neoplastic Disorder
- Infarction
- Myocardial Infarction
Pathways
- Localization
- Methylation
- Nuclear Import
- Neural Tube Closure
- Cell Proliferation
- Dna Methylation
- Viral Genome Expression
- Tube Closure
- Axis Specification
- Translation
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MDFI
bosterbio.com/bosterbio-gene-info-cards/MDFI
References
PMID: 9250874 by Kraut N.; The gene encoding I-mf (Mdfi) maps to human chromosome 6p21 and mouse chromosome 17.
PMID: 17289077 by Wang Q., et al. Developmental regulators containing the I-mfa domain interact with T cyclins and Tat and modulate transcription.