- Table of Contents
Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 contributes to cell lysis.
|MHC class I family|
|Sequence:||6; NC_000006.12 (31494881..31511124)|
Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue.
Cell membrane; Single-pass type I membrane protein. Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum.