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- Table of Contents
Facts about Calcium uptake protein 2, mitochondrial.
MICU2 functions as a gatekeeper of MCU that senses calcium level through its EF-hand domain names: prevents channel opening at resting Ca(2+), avoiding energy dissipation and cell-death tripping (PubMed:24560927). .
Mouse | |
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Gene Name: | Micu2 |
Uniprot: | Q8CD10 |
Entrez: | 68514 |
Belongs to: |
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MICU1 family |
Calcium uptake protein 2, mitochondrial
Mass (kDA):
49.476 kDA
Mouse | |
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Location: | 14|14 C3 |
Sequence: | 14; |
Predominantly expressed in stomach, intestine, skeletal muscle, kidney, heart, testis, prostate and uterus.
PMID: 23409044 by Plovanich M., et al. MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling.
PMID: 24560927 by Patron M., et al. MICU1 and MICU2 finely tune the mitochondrial Ca(2+) uniporter by exerting opposite effects on MCU activity.