MIER1 Antibodies

AND MIER1 ELISA kits, MIER1 Proteins

Many biological assays use antibodies to detect MIER1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MIER1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MIER1 antibodies...

We validate the specificity of these antibodies to MIER1 by testing them on tissues known to express MIER1 positively and negatively. Browse below to find the MIER1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MIER1 Infographic by Boster Bio

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MIER1 Overview

Facts about Mesoderm induction early response protein 1.

MIER1 3D structure. Source: alphafold

Mesoderm induction early response protein 1 (MIER1)

Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing.

Gene Information

Human
Gene Name:	MIER1
Uniprot:	Q8N108
Entrez:	57708

Family

Belongs to:

No superfamily

Alternative Names

DKFZp781G0451; Early response 1; ER1; hMI-ER1; KIAA1610MI-ER1; mesoderm induction early response 1 (MI-ER1); mesoderm induction early response 1 homolog (Xenopus laevis); mesoderm induction early response protein 1; MGC131940; MGC150640; MGC150641; Mi-er1

Molecular Weight

Mass (kDA):
57.983 kDA

Genomic Context


Human

Location:	1p31.3
Sequence:	1; NC_000001.11 (66924895..66988619)

Tissue Specificity

Ubiquitously expressed, but at very low levels. However, consistent level of expression are observed in heart, testis, thyroid, ovary and adrenal gland. Transcripts are up-regulated in breast carcinoma cell lines and tumor.

Subcellular Localizations

[Isoform 1]: Nucleus.; [Isoform 2]: Nucleus.; [Isoform 3]: Nucleus.; [Isoform 4]: Cytoplasm.; [Isoform 5]: Cytoplasm.; [Isoform 6]: Cytoplasm.

Diseases

Malignant Neoplasm Of Breast
Carcinoma
Malignant Neoplasms
Mammary Neoplasms
Invasive Breast Carcinoma
Cell Transformation, Neoplastic
Cardiomyopathy, Familial Idiopathic
Malignant Paraganglionic Neoplasm
Neoplasms

Noninfiltrating Intraductal Carcinoma
Carcinoma, Lobular
Hyperplasia
Ductal Breast Carcinoma

Interacting Proteins

HDAC1
TMEM171

Pathways

Localization
Cell Proliferation
Translation
Nuclear Export
Chromatin Remodeling

PTMs

Isopeptide bond

Phosphoprotein

Ubl conjugation

Research Areas

Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MIER1

References

PMID: 12242014 by Paterno G.D., et al. Genomic organization of the human mi-er1 gene and characterization of alternatively spliced isoforms: regulated use of a facultative intron determines subcellular localization.

PMID: 12482978 by Ding Z., et al. Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain.