MIOS Antibodies

AND MIOS ELISA kits, MIOS Proteins

Many biological assays use antibodies to detect MIOS, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MIOS in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MIOS antibodies...

We validate the specificity of these antibodies to MIOS by testing them on tissues known to express MIOS positively and negatively. Browse below to find the MIOS antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MIOS Infographic by Boster Bio

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MIOS (NM_019005) Human Over-expression Lysate

Human

$960
Cat # LS054468
20 µg, 100 µg

MIOS Overview

Facts about GATOR complex protein MIOS.

MIOS 3D structure. Source: alphafold

GATOR complex protein MIOS (MIOS)

As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing division of this TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238).

It is negatively regulated by the upstream amino acid detectors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). .

Gene Information

Human
Gene Name:	MIOS
Uniprot:	Q9NXC5
Entrez:	54468

Family

Belongs to:

WD repeat mio family

Alternative Names

FLJ20323; MIO; MIOS; missing oocyte, meiosis regulator, homolog (Drosophila); WD repeat-containing protein mio

Molecular Weight

Mass (kDA):
98.584 kDA

Genomic Context


Human

Location:	7p21.3
Sequence:	7; NC_000007.14 (7566875..7609144)

Subcellular Localizations

Lysosome membrane.

Diseases

Bone Neoplasms
Osteosarcoma
Deep Wound Injury
Neoplasm Metastasis
Infarction
Metastatic Malignant Neoplasm To The Lung
Coronary Artery Disease
Comminuted Fracture Type
Fracture
Wound Infection
Myocardial Infarction
Neoplasms

Algodystrophic Syndrome
Intra-articular Fractures
Neoplasm Recurrence, Local
Lung Neoplasms
Primary Neoplasm
Angina Pectoris

Interacting Proteins

SESN2
WDR24

Pathways

Wound Healing

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MIOS

References

PMID: 23723238 by Bar-Peled L., et al. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.

PMID: 25263562 by Chantranupong L., et al. The Sestrins interact with GATOR2 to negatively regulate the amino- acid-sensing pathway upstream of mTORC1.