GATOR complex protein MIOS (MIOS)

As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing division of this TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238).

It is negatively regulated by the upstream amino acid detectors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). .