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- Table of Contents
Facts about GATOR complex protein MIOS.
It is negatively regulated by the upstream amino acid detectors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). .
Human | |
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Gene Name: | MIOS |
Uniprot: | Q9NXC5 |
Entrez: | 54468 |
Belongs to: |
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WD repeat mio family |
FLJ20323; MIO; MIOS; missing oocyte, meiosis regulator, homolog (Drosophila); WD repeat-containing protein mio
Mass (kDA):
98.584 kDA
Human | |
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Location: | 7p21.3 |
Sequence: | 7; NC_000007.14 (7566875..7609144) |
Lysosome membrane.
PMID: 23723238 by Bar-Peled L., et al. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
PMID: 25263562 by Chantranupong L., et al. The Sestrins interact with GATOR2 to negatively regulate the amino- acid-sensing pathway upstream of mTORC1.