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- Table of Contents
Facts about Protein AF-10.
Binds to cruciform DNA. In cells, binding to unmodified histone H3 modulates DOT1L functions including histone H3'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302).
Human | |
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Gene Name: | MLLT10 |
Uniprot: | P55197 |
Entrez: | 8028 |
Belongs to: |
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No superfamily |
AF10MGC75086; ALL1-fused gene from chromosome 10 protein; DKFZp686E10210; myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog);translocated to, 10; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila);translocated to, 10; protein AF-10; type I AF10 protein
Mass (kDA):
113.32 kDA
Human | |
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Location: | 10p12.31 |
Sequence: | 10; NC_000010.11 (21524616..21743630) |
Expressed abundantly in testis.
Nucleus.
PMID: 7888665 by Chaplin T., et al. A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia.
PMID: 15851025 by Okada Y., et al. hDOT1L links histone methylation to leukemogenesis.