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MMP20 Antibodies
AND MMP20 ELISA kits, MMP20 Proteins
Many biological assays use antibodies to detect MMP20, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MMP20 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MMP20 antibodies...
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MMP20 Overview
Facts about Matrix metalloproteinase-20.
Matrix metalloproteinase-20 (MMP20)
Degrades amelogenin, the major protein component of the enamel matrix and 2 of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation.
Cleaves aggrecan at the'360-Asn-.
Gene Information
| Human | |
|---|---|
| Gene Name: | MMP20 |
| Uniprot: | O60882 |
| Entrez: | 9313 |
Family
| Belongs to: |
|---|
| peptidase M10A family |
Alternative Names
AI2A2; EC 3.4.24; EC 3.4.24.-; EC 3.4.24.22; EC 3.4.24.35; Enamel metalloproteinase; Enamelysin; matrix metallopeptidase 20; matrix metalloproteinase 20 (enamelysin); matrix metalloproteinase-20; MMP-20
Molecular Weight
Mass (kDA):
54.387 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q22.2 |
| Sequence: | 11; NC_000011.10 (102576832..102625332, complement) |
Tissue Specificity
Expressed specifically in the enamel organ.
Subcellular Localizations
Secreted, extracellular space, extracellular matrix.
Diseases
- Amelogenesis Imperfecta
- Dental Fluorosis, Acquired
- Dental Enamel Hypoplasia
- Neoplasms
- Ameloblastoma
- Odontogenic Tumors
- Dysplasia
- Congenital Absence
- Dental Caries
- Calcifying Odontogenic Cyst
- Odontogenic Cysts
- Carcinoma
Pathways
- Amelogenesis
- Secretion
- Localization
- Enamel Mineralization
- Cell Differentiation
- Dentin Mineralization
- Regeneration
- Dentinogenesis
- Proteolysis
- Protein Secretion
- Odontogenesis
- Pathogenesis
- Odontoblast Differentiation
PTMs
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MMP20
bosterbio.com/bosterbio-gene-info-cards/MMP20
References
PMID: 9398237 by Llano E., et al. Identification and structural and functional characterization of human enamelysin (MMP-20).
PMID: 10922468 by Stracke J.O., et al. Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP).