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- Table of Contents
Facts about Matrix metalloproteinase-21.
Cleaves alpha-1-antitrypsin (PubMed:12617721). .
Human | |
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Gene Name: | MMP21 |
Uniprot: | Q8N119 |
Entrez: | 118856 |
Belongs to: |
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peptidase M10A family |
EC 3.4.24; EC 3.4.24.-; matrix metallopeptidase 21; matrix metalloproteinase 21; matrix metalloproteinase-21; MMP-21
Mass (kDA):
65.043 kDA
Human | |
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Location: | 10q26.2 |
Sequence: | 10; NC_000010.11 (125766453..125775821, complement) |
Identified in fetal brain, kidney and liver. In adult tissues found primarily in ovary, kidney, liver, lung, placenta, brain and peripheral blood leukocytes. Expressed as well in various cancer cell lines.
Secreted.
PMID: 12490321 by Ahokas K., et al. Matrix metalloproteinase-21, the human orthologue for XMMP, is expressed during fetal development and in cancer.
PMID: 12617721 by Marchenko G.N., et al. The structure and regulation of the human and mouse matrix metalloproteinase-21 gene and protein.