Transcriptional activator MN1 (MN1)

Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the palate. Required during later phases of palate development for expansion and medial fusion of the palatal shelves.

Promotes maturation and normal use of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity).