MORC3 Antibodies

AND MORC3 ELISA kits, MORC3 Proteins

Many biological assays use antibodies to detect MORC3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MORC3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MORC3 antibodies...

We validate the specificity of these antibodies to MORC3 by testing them on tissues known to express MORC3 positively and negatively. Browse below to find the MORC3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for MORC3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the MORC3 Western Blot Guide

Designing an IHC experiment for MORC3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the MORC3 IHC Guide

MORC3 Infographic by Boster Bio

All MORC3 Products

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Product

Figures

Specificity

Applications

Price

Anti-MORC3 Antibody Picoband®

Western blot analysis of MORC3 using anti-MORC3 antibody (A06075-4)

IHC analysis of MORC3 using anti-MORC3 antibody (A06075-4)

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A06075-4
100 μg/vial

MORC3 (NM_015358) Human Over-expression Lysate

Human

$628
Cat # LS023515
20 µg, 100 µg

MORC3 Overview

Facts about MORC family CW-type zinc finger protein 3.

MORC3 3D structure. Source: alphafold

MORC family CW-type zinc finger protein 3 (MORC3)

Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696).

Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593).

Gene Information

Human
Gene Name:	MORC3
Uniprot:	Q14149
Entrez:	23515

Family

Belongs to:

No superfamily

Alternative Names

KIAA0136; MORC family CW-type zinc finger 3; MORC family CW-type zinc finger protein 3; nuclear matrix protein NXP2; NXP2; ZCW5; ZCWCC3; Zinc finger CW-type coiled-coil domain protein 3; zinc finger, CW type with coiled-coil domain 3; zinc finger, CW-type with coiled-coil domain 3

Molecular Weight

Mass (kDA):
107.113 kDA

Genomic Context


Human

Location:	21q22.12
Sequence:	21; NC_000021.9 (36320189..36376646)

Tissue Specificity

Expressed in heart, placenta, skeletal muscle, brain, pancreas, lung, liver, but not kidney.

Subcellular Localizations

Nucleus, nucleoplasm. Nucleus matrix. Nucleus, PML body. Also found in PML-independent nuclear bodies. Localization to nuclear bodies is ATP-dependent.

Diseases

Dermatomyositis
Myopathy
Malignant Neoplasms
Neoplasms
Acute Promyelocytic Leukemia
Lupus Erythematosus, Systemic
Myositis
Pulmonary Fibrosis
Leukemia
Calcinosis
Sclerosis
Neoplasm Metastasis

Polymyositis
Down Syndrome
Lung Diseases
Heart Block
Diffuse Scleroderma
Dermatomyositis, Childhood Type
Carcinoma

Pathways

Senescence
Cellular Senescence
Localization
Methylation
Cellular Process
Cardiac Conduction

PTMs

Sumoylation
Phosphorylation

Biotinylation
Acetylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MORC3

References

PMID: 11927593 by Kimura Y., et al. The newly identified human nuclear protein NXP-2 possesses three distinct domains, the nuclear matrix-binding, RNA-binding, and coiled- coil domains.

PMID: 17332504 by Takahashi K., et al. Dynamic regulation of p53 subnuclear localization and senescence by MORC3.