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- Table of Contents
Myelin protein P0 Antibodies
AND MPZ ELISA kits, Myelin protein P0 Proteins
Many biological assays use antibodies to detect Myelin protein P0, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Myelin protein P0 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Myelin protein P0 antibodies...
Designing a Western blot for Myelin protein P0? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MPZ Western Blot GuideMPZ Infographic by Boster Bio
All MPZ Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, WB
$370
Cat # A00997-1
100 μg/vial
Cat # A00997-1
100 μg/vial
Human
$628
Cat # LS004359
20 µg, 100 µg
Cat # LS004359
20 µg, 100 µg
MPZ Overview
Facts about Myelin protein P0.
Myelin protein P0 (MPZ)
Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and drives myelin compaction.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | MPZ |
| Uniprot: | P25189 |
| Entrez: | 4359 |
Family
| Belongs to: |
|---|
| myelin P0 protein family |
Alternative Names
Charcot-Marie-Tooth neuropathy 1B; CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; HMSNIB; MPP; Myelin peripheral protein; myelin protein P0; myelin protein zeroDSS; P0
Molecular Weight
Mass (kDA):
27.555 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q23.3 |
| Sequence: | 1; NC_000001.11 (161303594..161309969, complement) |
Tissue Specificity
Found only in peripheral nervous system Schwann cells.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein.; [Isoform L-MPZ]: Myelin membrane; Single-pass type I membrane protein.
Diseases
- Charcot-marie-tooth Disease
- Peripheral Neuropathy
- Hereditary Motor And Sensory Neuropathies
- Inherited Neuropathy
- Dejerine-sottas Disease (disorder)
- Demyelinating Diseases
- Nervousness
- Polyneuropathy
- Sensory Neuropathy
- Tissue Adhesions
- Congenital Hypomyelinating Neuropathy
Pathways
- Myelination
- Pathogenesis
- Secretion
- Meiosis
- Localization
- Muscle Atrophy
- Transport
- Translation
- Myelin Maintenance
- Cell Proliferation
- Regeneration
- Corticosterone Secretion
- Aging
PTMs
- Phosphorylation
- Reduction
Research Areas
- Neuronal Cell Markers
- Oligodendrocyte Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MPZ
bosterbio.com/bosterbio-gene-info-cards/MPZ
References
PMID: 1719967 by Hayasaka K., et al. Isolation and sequence determination of cDNA encoding the major structural protein of human peripheral myelin.
PMID: 7688964 by Hayasaka K., et al. Mutation of the myelin P0 gene in Charcot-Marie-Tooth neuropathy type 1.