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- Table of Contents
MR1 Antibodies
AND MR1 ELISA kits, MR1 Proteins
Many biological assays use antibodies to detect MR1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MR1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MR1 antibodies...
Designing a Western blot for MR1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MR1 Western Blot GuideMR1 Infographic by Boster Bio
All MR1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00618-1
100 μg/vial
Cat # A00618-1
100 μg/vial
MR1 Overview
Facts about Major histocompatibility complex class I-related gene protein.
Major histocompatibility complex class I-related gene protein (MR1)
Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and growth of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T- cells (MAIT).
MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.
Gene Information
| Human | |
|---|---|
| Gene Name: | MR1 |
| Uniprot: | Q95460 |
| Entrez: | 3140 |
Family
| Belongs to: |
|---|
| MHC class I family |
Alternative Names
Class I histocompatibility antigen-like protein; FLJ31593; H2ls; HLALS; major histocompatibility complex class I-related gene protein; major histocompatibility complex, class I-like sequence; major histocompatibility complex, class I-related; MHC class I-like antigen MR-1; MHC class I-related gene protein; MHC class-I related-gene protein; MR1
Molecular Weight
Mass (kDA):
39.366 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q25.3 |
| Sequence: | 1; NC_000001.11 (181033392..181061938) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Cell membrane; Single-pass membrane protein; Extracellular side. Endoplasmic reticulum.; [Isoform 4]: Secreted.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane. The larger proportion remains in the ER in an immature state. The subset that reach cell surface does it through a B2M-independent pathway.
Diseases
- Neoplasms
- Autoimmune Reaction
- Malignant Neoplasms
- Autoimmunity
- Decreased Immunologic Activity [pe]
- Fibrosis
- Inflammation
- Sclerosis
- Infective Disorder
- Bacterial Infections
- Autoimmune Diseases
- Depressive Disorder
- Diabetes Mellitus, Experimental
Interacting Proteins
- B2M
- FATE1
Pathways
- Immune Response
- Cell Activation
- Cytokine Production
- Tolerance Induction
- Cell Proliferation
- Pathogenesis
- Cell Development
- Localization
- Cell Death
- Secretion
- T Cell Activation
- Sensitization
- Transport
PTMs
- Phosphorylation
- Glycosylation
- Nitration
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MR1
bosterbio.com/bosterbio-gene-info-cards/MR1
References
PMID: 7624800 by Hashimoto K., et al. A gene outside the human MHC related to classical HLA class I genes.
PMID: 11019920 by Parra-Cuadrado J.F., et al. A study on the polymorphism of human MHC class I-related MR1 gene and identification of an MR1-like pseudogene.