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- Table of Contents
MRE11 Antibodies
AND MRE11 ELISA kits, MRE11 Proteins
Many biological assays use antibodies to detect MRE11, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MRE11 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MRE11 antibodies...
Designing a Western blot for MRE11? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MRE11 Western Blot GuideDesigning an IHC experiment for MRE11? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the MRE11 IHC GuideMRE11 Infographic by Boster Bio
All MRE11 Products
Product
Figures
Specificity
Applications
Price
Anti-MRE11 Antibody Picoband®
2 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A32234
100 μg/vial
Cat # A32234
100 μg/vial
Human, Mouse, Rat
ELISA, IHC, WB
$370
Cat # A00731-2
100 μg/vial
Cat # A00731-2
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A32234-1
100 μg/vial
Cat # A32234-1
100 μg/vial
Anti-Mre11 MRE11A Rabbit Monoclonal Antibody
1 Citations
Human, Mouse, Rat
IHC, WB
$370
Cat # M00731
100 μl
Cat # M00731
100 μl
Human, Mouse, Rat
ELISA
$540
Cat # EKC2334
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2334
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1385
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1385
1 kit, containing one 96-well plate and all necessary reagents
MRE11 Overview
Facts about Double-strand break repair protein MRE11.
Double-strand break repair protein MRE11 (MRE11)
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11.
RAD50 could be asked to bind DNA ends and hold them in close proximity. This may facilitate searches for long or short regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to stop nucleolytic degradation beyond a given point (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289).
Gene Information
| Human | |
|---|---|
| Gene Name: | MRE11 |
| Uniprot: | P49959 |
| Entrez: | 4361 |
Family
| Belongs to: |
|---|
| MRE11/RAD32 family |
Alternative Names
ATLDmeiotic recombination (S. cerevisiae) 11 homolog A; AT-like disease; DNA recombination and repair protein; double-strand break repair protein MRE11A; endo/exonuclease Mre11; HNGS1; Meiotic recombination 11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog 1; MRE11 homolog A; MRE11 meiotic recombination 11 homolog A (S. cerevisiae); Mre11; MRE11A; MRE11MRE11B
Molecular Weight
Mass (kDA):
80.593 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q21 |
| Sequence: | 11; NC_000011.10 (94415570..94512701, complement) |
Subcellular Localizations
Nucleus. Chromosome, telomere. Chromosome. Localizes to discrete nuclear foci after treatment with genotoxic agents.
Diseases
- Malignant Neoplasms
- Ataxia Telangiectasia
- Neoplasms
- Ataxia
- Nijmegen Breakage Syndrome
- Genomic Instability
- Telangiectasis
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Chromosome Breakage
- Cell Transformation, Neoplastic
- Carcinoma
Interacting Proteins
- FANCD2
- H2AFX
- HTT
- NBN
- RAD17
- RBBP8
Pathways
- Dna Repair
- Cell Cycle
- Dna Replication
- Double-strand Break Repair
- Telomere Maintenance
- S Phase
- Dna Damage Checkpoint
- Cell Cycle Checkpoint
- Mismatch Repair
- Localization
- Viral Replication
- Hypersensitivity
- Cell Cycle Arrest
PTMs
- Phosphorylation
- Methylation
- Cleavage
- Acetylation
- Deamination
Research Areas
- Breast Cancer
- Cancer
- Cell Cycle and Replication
- Checkpoint signaling
- Chromatin Research
- DNA Double Strand Break Repair
- DNA Repair
- Homologous Recombination
- Non-homologous end-joining
- Protein Phosphatase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MRE11
bosterbio.com/bosterbio-gene-info-cards/MRE11
References
PMID: 8530104 by Petrini J.H.J., et al. Isolation and characterization of the human MRE11 homologue.
PMID: 9651580 by Paull T.T., et al. The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks.