Mas-related G-protein coupled receptor member D (MRGPRD)

May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a particular membrane receptor for beta-alanine.

Beta-alanine at micromolar doses especially evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin- stimulated cAMP production in cells expressing the receptor, indicating that the receptor couples with G-protein G(q) and G(I).