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- Table of Contents
MSL2 Antibodies
AND MSL2 ELISA kits, MSL2 Proteins
Many biological assays use antibodies to detect MSL2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MSL2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MSL2 antibodies...
Designing a Western blot for MSL2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MSL2 Western Blot GuideMSL2 Infographic by Boster Bio
All MSL2 Products
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Specificity
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MSL2 Overview
Facts about E3 ubiquitin-protein ligase MSL2.
E3 ubiquitin-protein ligase MSL2 (MSL2)
Component of histone acetyltransferase complex responsible for nearly all histone H4 acetylation at lysine 16 which is implicated in the creation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B in'Lys-35' (H2BK34Ub), but not that of H2A.
This action is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation in'Lys-4' (H3K4me) and'Lys-79' (H3K79me) and results in gene activation, such as that of HOXA9 and MEIS1.
Gene Information
| Human | |
|---|---|
| Gene Name: | MSL2 |
| Uniprot: | Q9HCI7 |
| Entrez: | 55167 |
Family
| Belongs to: |
|---|
| MSL2 family |
Alternative Names
FLJ10546; KIAA1585FLJ54913; male-specific lethal 2 homolog (Drosophila); male-specific lethal 2 homolog; male-specific lethal 2-like 1 (Drosophila); Male-specific lethal 2-like 1; Male-specific lethal-2 homolog 1; MSL-2; MSL2L1; MSL2-like 1; PHNPCC4; PMS2; RING finger protein 184msl-2; RNF184
Molecular Weight
Mass (kDA):
62.541 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q22.3 |
| Sequence: | 3; NC_000003.12 (136148917..136197300, complement) |
Diseases
- Multiple Organ Failure
- Monosomy
- Cell Transformation, Neoplastic
- Tense
- Epithelial Ovarian Cancer
- Ovarian Neoplasm
Pathways
- Dosage Compensation
- Localization
- Methylation
- Translation
- Rna Interference
- Transport
- Chromosome Localization
- Photosynthesis
- Proteolysis
- Nuclear Export
- Cell Cycle Arrest
- Cellular Response To Osmotic Stress
- Response To Osmotic Stress
PTMs
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MSL2
bosterbio.com/bosterbio-gene-info-cards/MSL2
References
PMID: 16227571 by Smith E.R., et al. A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16.
PMID: 16543150 by Mendjan S., et al. Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila.