Humanin Antibodies

AND MT-RNR2 ELISA kits, Humanin Proteins

Many biological assays use antibodies to detect Humanin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Humanin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Humanin antibodies...

We validate the specificity of these antibodies to Humanin by testing them on tissues known to express MT-RNR2 positively and negatively. Browse below to find the MT-RNR2 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MT-RNR2 Infographic by Boster Bio

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MT-RNR2 Overview

Facts about Humanin.

MT-RNR2 3D structure. Source: alphafold

Humanin (MT-RNR2)

Plays a role as a neuroprotective element. Protects against death induced by numerous familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease.

Suppresses apoptosis by binding to BAX and preventing the translocation of BAX from the cytosol into mitochondria. Binds to IGFBP3 and especially blocks IGFBP3-induced cell death Induces chemotaxis of mononuclear phagocytes through FPR2.

Gene Information

Human
Gene Name:	MT-RNR2
Uniprot:	Q8IVG9
Entrez:

Family

Belongs to:

humanin family

Alternative Names

Humanin

Molecular Weight

Mass (kDA):
2.687 kDA

Genomic Context


Human

Location:
Sequence:	;

Tissue Specificity

Expressed in the heart, skeletal muscles, kidney and liver. Lesser but significant expression is observed in the brain and the gastrointestinal tract. Expressed in the AD brain, where it is found in some of the large intact neurons of the occipital lobes and small and round reactive glial cells in the hippocampus.

Subcellular Localizations

Secreted. Cytoplasm.

Interacting Proteins

APP
BAX
IGFBP3

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MT-RNR2

References

PMID: 11371646 by Hashimoto Y., et al. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta.

PMID: 14561895 by Ikonen M., et al. Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis.