MTPAP Antibodies

AND MTPAP ELISA kits, MTPAP Proteins

Many biological assays use antibodies to detect MTPAP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MTPAP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MTPAP antibodies...

We validate the specificity of these antibodies to MTPAP by testing them on tissues known to express MTPAP positively and negatively. Browse below to find the MTPAP antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MTPAP Infographic by Boster Bio

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Poly(A) RNA polymerase, mitochondrial (MTPAP) (NM_018109) Human Over-expression Lysate

Human

$628
Cat # LS055149
20 µg, 100 µg

MTPAP Overview

Facts about Poly(A) RNA polymerase, mitochondrial.

MTPAP 3D structure. Source: alphafold

Poly(A) RNA polymerase, mitochondrial (MTPAP)

Polymerase that produces the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has greater activity with ATP and UTP (in vitro).

Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs until their degradation is initiated.

Gene Information

Human
Gene Name:	MTPAP
Uniprot:	Q9NVV4
Entrez:	55149

Family

Belongs to:

DNA polymerase type-B-like family

Alternative Names

EC 2.7.7.19; FLJ10486; mitochondrial poly(A) polymerase; mtPAP; PAP associated domain containing 1; PAP; PAP-associated domain-containing protein 1; PAPD1SPAX4; poly(A) RNA polymerase, mitochondrial; Polynucleotide adenylyltransferase; Terminal uridylyltransferase 1; TUTase 1

Molecular Weight

Mass (kDA):
66.172 kDA

Genomic Context


Human

Location:	10p11.23
Sequence:	10; NC_000010.11 (30309801..30349338, complement)

Tissue Specificity

Ubiquitous, with stronger expression in tissues with high energy requirements: heart, brain, and skeletal muscle.

Subcellular Localizations

Cytoplasm. Mitochondrion.

Diseases

Optic Atrophy
Paraparesis, Spastic
Neurodegenerative Disorders
Ataxia
Cerebellar Ataxia
Atrophy

Interacting Proteins

Azi2
CALCOCO2
TBK1

Pathways

Chromosome Localization
Translation
Cell Differentiation
Rna Polyadenylation
Rna Interference
Localization

PTMs

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MTPAP

References

PMID: 15547249 by Tomecki R., et al. Identification of a novel human nuclear-encoded mitochondrial poly(A) polymerase.

PMID: 15769737 by Nagaike T., et al. Human mitochondrial mRNAs are stabilized with polyadenylation regulated by mitochondria-specific poly(A) polymerase and polynucleotide phosphorylase.