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- Table of Contents
Facts about Mucin-12.
Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium. .
Human | |
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Gene Name: | MUC12 |
Uniprot: | Q9UKN1 |
Entrez: | 10071 |
Belongs to: |
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No superfamily |
MUC11; MUC-11; MUC-12; mucin 11; mucin 12, cell surface associated; mucin-11; mucin-12
Mass (kDA):
558.164 kDA
Human | |
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Location: | 7q22.1 |
Sequence: | 7; NC_000007.14 (100969623..101018949) |
Ubiquitous, with higher expression in colon. Down-regulated in colorectal cancer as well as in the colon of patients with ulcerative colitis (UC) and Crohn's disease (CD).
Membrane; Single-pass type I membrane protein.
PMID: 10463611 by Williams S.J., et al. Two novel mucin genes down-regulated in colorectal cancer identified by differential display.
PMID: 11341784 by Parry S., et al. Identification of MUC1 proteolytic cleavage sites in vivo.