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- Table of Contents
Facts about Myosin-10.
During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (from the central part but not the margins of spreading cells), and lamellipodial extension; this purpose is mechanically antagonized by MYH9. .
Human | |
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Gene Name: | MYH10 |
Uniprot: | P35580 |
Entrez: | 4628 |
Belongs to: |
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TRAFAC class myosin-kinesin ATPase superfamily |
cellular myosin heavy chain, type B type B; Cellular myosin heavy chain, type B; heavy polypeptide 10, non-muscle; MGC134913; MGC134914; Myosin heavy chain 10; Myosin heavy chain, non-muscle IIb; myosin heavy chain, nonmuscle type B; myosin, heavy chain 10, non-muscle; myosin-10; near to the ATP binding region; NMMHC II-b; NMMHCB; NMMHC-B; NMMHC-IIB; Non-muscle myosin heavy chain B; nonmuscle myosin heavy chain IIB; Non-muscle myosin heavy chain IIb; nonmuscle myosin heavy chain-B; nonmuscle myosin II heavy chain-B
Mass (kDA):
228.999 kDA
Human | |
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Location: | 17p13.1 |
Sequence: | 17; NC_000017.11 (8474205..8631369, complement) |
Isoform 1 is expressed in cerebellum and spinal chord. Isoform 2 is expressed in cerebrum and retina. Isoform 3 is expressed in the cerebrum and to a much lower extent in cerebellum.
Cell projection, lamellipodium. Colocalizes with MCC at the leading edge of migrating cells.
PMID: 7499478 by Phillips C.L., et al. Cloning of the cDNA encoding human nonmuscle myosin heavy chain-B and analysis of human tissues with isoform-specific antibodies.
PMID: 8690889 by Abdelhaleem M.M., et al. Leukophysin: an RNA helicase A-related molecule identified in cytotoxic T cell granules and vesicles.
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