Unconventional myosin-Ie Antibodies

AND MYO1E ELISA kits, Unconventional myosin-Ie Proteins

Many biological assays use antibodies to detect Unconventional myosin-Ie, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Unconventional myosin-Ie in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Unconventional myosin-Ie antibodies...

We validate the specificity of these antibodies to Unconventional myosin-Ie by testing them on tissues known to express MYO1E positively and negatively. Browse below to find the MYO1E antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MYO1E Infographic by Boster Bio

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MYO1E (NM_004998) Human Over-expression Lysate

Human

$628
Cat # LS004643
20 µg, 100 µg

MYO1E Overview

Facts about Unconventional myosin-Ie.

MYO1E 3D structure. Source: alphafold

Unconventional myosin-Ie (MYO1E)

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements.

Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids through its tail domain.

Gene Information

Human
Gene Name:	MYO1E
Uniprot:	Q12965
Entrez:	4643

Family

Belongs to:

TRAFAC class myosin-kinesin ATPase superfamily

Alternative Names

HuncM-IC; MGC104638; MYO1Cmyosin-IC; MYO1E variant protein; myosin IE; Myosin-Ic; myosin-Ie

Molecular Weight

Mass (kDA):
127.062 kDA

Genomic Context


Human

Location:	15q22.2
Sequence:	15; NC_000015.10 (59132434..59372871, complement)

Tissue Specificity

Expressed in the immune system. In the kidney, predominantly expressed in the glomerulus, including podocytes.

Subcellular Localizations

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Cell junction. Colocalizes with F-actin (By similarity). In cultured podocytes, it localizes close to and is associated with the cytoplasmic membrane, with enrichment at the lamellipodia tips. Colocalizes with cytoplasmic vesicles, including endocytic clathrin-coated vesicles. Colocalizes with dynamin at cytoplasmic vesicles.

Diseases

Segmental Glomerulosclerosis
Nephrotic Syndrome
Focal Glomerulosclerosis
Glomerulosclerosis (disorder)
Renal Glomerular Disease
Proteinuria Of Undiagnosed Cause
Kidney Diseases
Inflammation
Varicosity
Malignant Tumor Of Colon
Steroid-resistant Nephrotic Syndrome
Endometrial Polyp
Primary Focal Segmental Glomerulosclerosis

Carcinoma
Injury To Kidney
Endometritis
Malignant Neoplasms
Flushing
Neoplasms
Puerperal Disorders

Interacting Proteins

ARL14EP
Dnm1
DNM2
Synj1

Pathways

Localization
Endocytosis
Glomerular Filtration
Clathrin-mediated Endocytosis
Cell Cycle
Receptor-mediated Endocytosis
Cell Adhesion
Methylation

Lipid Binding
Dna Repair
Dna Methylation

PTMs

Phosphorylation

Cleavage

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MYO1E

References

PMID: 7932763 by Bement W.M., et al. Cloning and mRNA expression of human unconventional myosin-IC. A homologue of amoeboid myosins-I with a single IQ motif and an SH3 domain.

PMID: 8022818 by Bement W.M., et al. Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types.