E3 ubiquitin-protein ligase MARCHF7 (Marchf7)

E3 ubiquitin-protein ligase which might specifically improve the E2 action of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

May be involved in T-cell proliferation by regulating LIF secretion. .