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- Table of Contents
MELK Antibodies
AND MELK ELISA kits, MELK Proteins
Many biological assays use antibodies to detect MELK, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MELK in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MELK antibodies...
Designing an IHC experiment for MELK? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the MELK IHC GuideMELK Infographic by Boster Bio
All MELK Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A04038-2
100 µg/vial
Cat # A04038-2
100 µg/vial
Human
ELISA
$480
Cat # EKC1811
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1811
1 kit, containing one 96-well plate and all necessary reagents
MELK Overview
Facts about Maternal embryonic leucine zipper kinase.
Maternal embryonic leucine zipper kinase (MELK)
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1.
Acts as a regulator of cell cycle, especially by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis.
Gene Information
| Human | |
|---|---|
| Gene Name: | MELK |
| Uniprot: | Q14680 |
| Entrez: | 9833 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11; EC 2.7.11.1; hMELK; HPK38; KIAA0175pEg3 kinase; maternal embryonic leucine zipper kinase; MELK; PK38; Protein kinase PK38
Molecular Weight
Mass (kDA):
74.642 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9p13.2 |
| Sequence: | 9; NC_000009.12 (36572862..36677683) |
Tissue Specificity
Expressed in placenta, kidney, thymus, testis, ovary and intestine.
Subcellular Localizations
Cell membrane; Peripheral membrane protein.
Diseases
- Malignant Neoplasms
- Neoplasms
- Brain Neoplasms
- Glioblastoma
- Malignant Paraganglionic Neoplasm
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Breast
- Glioma
- Colorectal Cancer
- Cell Invasion
- Glioblastoma Multiforme
- Medulloblastoma
Interacting Proteins
- BCL2L14
Pathways
- Cell Cycle
- Cell Proliferation
- Mitosis
- Anaphase
- Cytokinesis
- Cell Division
- Mrna Splicing
- Translation
- Mrna Processing
- Interphase
- Drug Resistance
- Dna Replication
- Rna Interference
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MELK
bosterbio.com/bosterbio-gene-info-cards/MELK
References
PMID: 11802789 by Seong H.-A., et al. Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38).
PMID: 12400006 by Davezac N., et al. Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation.