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- Table of Contents
MKNK1 Antibodies
AND MKNK1 ELISA kits, MKNK1 Proteins
Many biological assays use antibodies to detect MKNK1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MKNK1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MKNK1 antibodies...
Designing an IHC experiment for MKNK1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the MKNK1 IHC GuideMKNK1 Infographic by Boster Bio
All MKNK1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$540
Cat # EKC2620
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2620
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2571
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2571
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse
ELISA
$480
Cat # EKC1383
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1383
1 kit, containing one 96-well plate and all necessary reagents
MKNK1 Overview
Facts about MAP kinase-interacting serine/threonine-protein kinase 1.
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)
May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for your 7- methylguanosine-containing mRNA cap.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | MKNK1 |
| Uniprot: | Q9BUB5 |
| Entrez: | 8569 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11; EC 2.7.11.1; MAP kinase interacting kinase 1; MAP kinase interacting serine/threonine kinase 1; MAP kinase signal-integrating kinase 1; MAP kinase-interacting serine/threonine-protein kinase 1; Mnk1; MNK1MAP kinase-interacting serine/threonine kinase 1
Molecular Weight
Mass (kDA):
51.342 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p33 |
| Sequence: | 1; NC_000001.11 (46557407..46604311, complement) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
[Isoform 2]: Cytoplasm.; [Isoform 3]: Cytoplasm. Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Paraganglionic Neoplasm
- Cell Transformation, Neoplastic
- Mammary Neoplasms
- Lymphoma
- Metaplastic Cell Transformation
- Inflammation
- Leukemia
- Malignant Neoplasm Of Breast
- Carcinoma
- Glioma
Interacting Proteins
- MAPK1
- MAPK14
Pathways
- Translation
- Cell Growth
- Cell Proliferation
- Localization
- Hyperphosphorylation
- Nuclear Export
- Viral Replication
- Transport
- Cell Differentiation
- Cell Death
- Pathogenesis
- Cell Adhesion
- Muscle Cell Proliferation
PTMs
- Phosphorylation
- Dephosphorylation
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MKNK1
bosterbio.com/bosterbio-gene-info-cards/MKNK1
References
PMID: 9155018 by Fukunaga R., et al. MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates.
PMID: 11463832 by Knauf U., et al. Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2.