Target of rapamycin complex subunit LST8 (Mlst8)

Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to hormonal and nutrient signals. mTORC1 is activated in response to growth factors or amino acids.

Growth factor-stimulated mTORC1 activation involves a AKT1- mediated phosphorylation of TSC1-TSC2, which leads to the activation of this RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling into mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complicated and the Rag GTPases.