MTNR1B Antibodies

AND MTNR1B ELISA kits, MTNR1B Proteins

Many biological assays use antibodies to detect MTNR1B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MTNR1B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MTNR1B antibodies...

We validate the specificity of these antibodies to MTNR1B by testing them on tissues known to express MTNR1B positively and negatively. Browse below to find the MTNR1B antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for MTNR1B? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the MTNR1B IHC Guide

MTNR1B Infographic by Boster Bio

All MTNR1B Products

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Anti-MTR1B MTNR1B Antibody

1 Citations

Immunohistochemical analysis of paraffin-embedded human liver cancer

Western Blot analysis of HepG2 cells using MEL-1B-R Polyclonal Antibody diluted at 1:1000

Western Blot analysis of various cells using MEL-1B-R Polyclonal Antibody diluted at 1:1000

Human

IHC, WB

$335
Cat # A30844
100ul

MTNR1B Overview

Facts about Melatonin receptor type 1B.

MTNR1B 3D structure. Source: alphafold

Melatonin receptor type 1B (MTNR1B)

High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin.

The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. .

Gene Information

Human
Gene Name:	MTNR1B
Uniprot:	P49286
Entrez:	4544

Family

Belongs to:

G-protein coupled receptor 1 family

Alternative Names

FGQTL2; Mel 1b melatonin receptor; Mel1b receptor; MEL-1B-R; melatonin receptor 1B; melatonin receptor MEL1B; melatonin receptor type 1B; MT2

Molecular Weight

Mass (kDA):
40.188 kDA

Genomic Context


Human

Location:	11q14.3
Sequence:	11; NC_000011.10 (92969651..92986241)

Tissue Specificity

Expressed in retina and less in brain and hippocampus.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Diseases

Diabetes Mellitus
Diabetes Mellitus, Non-insulin-dependent
Insulin Resistance
Hyperglycemia
Insulin Sensitivity
Dysequilibrium Syndrome
Obesity
Scoliosis, Unspecified
Adolescent Idiopathic Scoliosis
Impaired Glucose Tolerance
Prediabetes Syndrome

Gestational Diabetes
Malignant Neoplasms
Cholangiocarcinoma
Cardiovascular Diseases
Metabolic Syndrome X
Hypertensive Disease

Interacting Proteins

HTR2C
MTNR1A
RGS20
TRIP12

Pathways

Secretion
Insulin Secretion
Glucose Homeostasis
Pathogenesis
Regulation Of Glucose Homeostasis
Cell Proliferation
Circadian Rhythm
Reproductive Process
Aging
Response To Metformin
Oocyte Maturation

Localization
Reverse Transcription
Insulin Processing
Exocytosis
Rna Interference

PTMs

Cleavage

Research Areas

GPCR
Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MTNR1B

References

PMID: 7568007 by Reppert S.M., et al. Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor.

PMID: 10696804 by Ebisawa T., et al. Genetic polymorphisms of human melatonin 1b receptor gene in circadian rhythm sleep disorders and controls.