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- Table of Contents
MZB1 Antibodies
AND MZB1 ELISA kits, MZB1 Proteins
Many biological assays use antibodies to detect MZB1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MZB1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MZB1 antibodies...
Designing a Western blot for MZB1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MZB1 Western Blot GuideDesigning an IHC experiment for MZB1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the MZB1 IHC GuideMZB1 Infographic by Boster Bio
All MZB1 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A08281-1
100 µg/vial
Cat # A08281-1
100 µg/vial
Human
$628
Cat # LS051237
20 µg, 100 µg
Cat # LS051237
20 µg, 100 µg
MZB1 Overview
Facts about Marginal zone B- and B1-cell-specific protein.
Marginal zone B- and B1-cell-specific protein (MZB1)
Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM secretion and assembly. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity).
Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation.
Gene Information
| Human | |
|---|---|
| Gene Name: | MZB1 |
| Uniprot: | Q8WU39 |
| Entrez: | 51237 |
Family
| Belongs to: |
|---|
| MZB1 family |
Alternative Names
caspase-2 binding protein; FLJ32987; HSPC190; marginal zone B and B1 cell-specific protein; MGC29506; PACAP; pERp1; plasma cell-induced ER protein 1; plasma cell-induced resident endoplasmic reticulum protein; Plasma cell-induced resident ER protein; Proapoptotic caspase adapter protein; proapoptotic caspase adaptor protein
Molecular Weight
Mass (kDA):
20.694 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q31.2 |
| Sequence: | 5; NC_000005.10 (139387467..139389913, complement) |
Tissue Specificity
Widely expressed with highest levels in adult brain, small intestine and lymphoid tissues such as thymus and spleen. Expression is frequently lower in intestinal-type gastric cancer. In obese patients, more abundant in omental than in subcutaneous fat.
Subcellular Localizations
[Isoform 1]: Endoplasmic reticulum lumen. Secreted.; [Isoform 2]: Cytoplasm. Diffuse granular localization in the cytoplasm surrounding the nucleus (PubMed:11350957).
Diseases
- Cell Transformation, Neoplastic
- Neoplasms
- Liver Carcinoma
- Liver Neoplasms
- Tissue Adhesions
- Hepatocarcinogenesis
Pathways
- Cell Adhesion
- Methylation
- Cell Proliferation
- Dna Hypermethylation
- Integrin Activation
- Localization
PTMs
Research Areas
- Apoptosis
- Caspases
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MZB1
bosterbio.com/bosterbio-gene-info-cards/MZB1
References
PMID: 11350957 by Bonfoco E., et al. Characterization of a novel proapoptotic caspase-2- and caspase-9- binding protein.
PMID: 19805157 by Shimizu Y., et al. pERp1 is significantly up-regulated during plasma cell differentiation and contributes to the oxidative folding of immunoglobulin.