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- Table of Contents
Facts about NEDD4-binding protein 1.
Inhibitor of the E3 ubiquitin-protein ligase ITCH.
Acts by interacting with the next WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity).. .
Human | |
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Gene Name: | N4BP1 |
Uniprot: | O75113 |
Entrez: | 9683 |
Belongs to: |
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N4BP1 family |
FLJ31821; KIAA0615; MGC176730; NEDD4 binding protein 1; NEDD4-binding protein 1
Mass (kDA):
100.379 kDA
Human | |
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Location: | 16q12.1 |
Sequence: | 16; NC_000016.10 (48538726..48610214, complement) |
Detected in heart, lung, brain, liver, skeletal muscle, pancreas, kidney, spleen, testis and ovary.
Nucleus, nucleolus. Nucleus, PML body. Primarily localizes to the nucleolus. Also localizes to the PML nuclear bodies, when desumoylated (By similarity).
PMID: 9734811 by Ishikawa K., et al. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
PMID: 15616553 by Martin J., et al. The sequence and analysis of duplication-rich human chromosome 16.