Nascent polypeptide-associated complex subunit alpha-2 (NACA2)

Prevents improper targeting of non-secretory polypeptides into the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides into the ER.

Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). .